| Effect of prior exercise on postprandial lipemia and markers of inflammation and endothelial activation in normal weight and overweight adolescent boys. | |
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MedLine Citation:
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PMID: 19430945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postprandial lipemia (PPL) is associated with impaired endothelial function and inflammation. Acute exercise reduces PPL in adults. This investigation examined the effect of an acute bout of exercise on postprandial changes in triglycerides (TG), glucose, insulin, inflammation [white blood cell count (WBC), interleukin-6 (IL-6) tumor necrosis factor-alpha, C-reactive protein (CRP)] and endothelial activation [soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1)] following a high-fat meal in adolescents. Ten normal weight (NW) (BMI, 20.9 +/- 1.7 kg m(-2); 15.6 +/- 0.7 years) and eight overweight (OW) (BMI, 28.3 +/- 3.6 kg m(-2); 15.9 +/- 0.4 years) adolescent boys underwent two 6-h oral fat tolerance tests (OFTT) separated by 7-10 days. On the evening prior to each OFTT, subjects either rested or completed a treadmill exercise bout (65% V(O)(2max); 600 kcal expended). Exercise reduced (P < 0.01) the postprandial TG area under the curve by approximately 20% in the NW and OW groups. The postprandial glucose and insulin response did not differ between the control and exercise trials or between the NW and OW groups. Circulating leukocytes and plasma IL-6 levels increased (P < 0.01) in the NW and OW groups 6 h following the OFTT in both experimental conditions. There were no changes in CRP, sVCAM-1 or sICAM-1 following the OFTT and there were no differences between experimental condition or NW and OW groups. In conclusion, a moderate exercise bout prior to a high-fat meal effectively reduces postprandial TG concentrations to a similar degree in both NW and OW adolescents, but does not reduce the concomitant postprandial increase in WBC or IL-6. |
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Authors:
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Owen J MacEneaney; Michael Harrison; Donal J O'Gorman; Elena V Pankratieva; Paul L O'Connor; Niall M Moyna |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-05-10 |
Journal Detail:
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Title: European journal of applied physiology Volume: 106 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-02 Completed Date: 2009-10-01 Revised Date: 2009-11-12 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 721-9 Citation Subset: IM |
Affiliation:
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Dublin City University, Dublin 9, Ireland. Owen.MacEneaney@Colorado.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Markers / blood* Blood Glucose / analysis Body Weight / physiology Endothelium, Vascular / physiopathology Exercise / physiology* Humans Hyperlipidemias / blood, physiopathology* Inflammation / blood*, physiopathology Insulin / blood Male Overweight / blood*, physiopathology Postprandial Period / physiology* Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Triglycerides; 11061-68-0/Insulin |
| Comments/Corrections | |
Comment In:
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Eur J Appl Physiol. 2009 Nov;107(5):621-2
[PMID:
19701768
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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