Document Detail


Effect of pretreatment with hydrocortisone on insulin secretory response to catecholamines in isolated islets from rats fed with a high fat diet.
MedLine Citation:
PMID:  6360699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Islets isolated from rats fed with a high fat diet for 7 days were pretreated with hydrocortisone, and in the treated-islets the effect of glucose, epinephrine and dopamine on insulin secretion was examined. Glucose-stimulated insulin secretion in the untreated islets was not changed by the fat diet. Insulin secretion stimulated by hydrocortisone (10(-6)M) in the presence of 2.8 mM glucose was twice higher in the control diet group than in the fat diet group. Pretreatment of the islets with hydrocortisone did not affect glucose-stimulated insulin secretion in the control diet group but remarkably reduced that in the fat diet group. Although the fat diet attenuated the inhibitory effect of catecholamines on insulin secretory response to glucose, pretreatment of the islets with hydrocortisone caused to restore the effect of catecholamines, especially at a low concentration. These results indicate that the combined action of a high fat diet and glucocorticoids may induce modification of alpha-adrenergic receptors in the B-cell.
Authors:
K Yamaguchi; A Matsuoka
Related Documents :
7040609 - Effects of high protein diet on insulin and glucagon secretion in normal rats.
2432459 - Accelerated growth and abnormal glucose tolerance in young female rats exposed to fetal...
8857509 - Dietary fat and sex modify heterozygote effects of the rat fatty (fa) allele.
20705119 - Contrasting effects of systemic and central sibutramine administration on the intake of...
21524549 - Short communication: effect of stocking rate on the economics of pasture-based dairy fa...
214469 - The concentration of cyclic amp and the activity of cyclic amp dependent protein kinase...
9197469 - Polyunsaturated fat in the diet may improve intestinal function in patients with crohn'...
7465509 - Evaluation of the efficacy of salinomycin in the control of coccidiosis in chicks.
19161199 - Improved fat suppression using multipeak reconstruction for ideal chemical shift fat-wa...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Experimental and clinical endocrinology     Volume:  82     ISSN:  0232-7384     ISO Abbreviation:  Exp. Clin. Endocrinol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302802     Medline TA:  Exp Clin Endocrinol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Catecholamines / physiology*
Dietary Fats / administration & dosage*
Dopamine / physiology
Drug Interactions
Epinephrine / physiology
Glucose / physiology
Hydrocortisone / pharmacology*
Insulin / secretion*
Islets of Langerhans / secretion*
Male
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Dietary Fats; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 50-99-7/Glucose; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute effects of maternal stress on fetal blood catecholamines and hypothalamic LH-RH content.
Next Document:  Quantification of the differential diagnosis of Cushing's syndrome using computers