Document Detail

Effect of pretreatment with hydrocortisone on insulin secretory response to catecholamines in isolated islets from rats fed with a high fat diet.
MedLine Citation:
PMID:  6360699     Owner:  NLM     Status:  MEDLINE    
Islets isolated from rats fed with a high fat diet for 7 days were pretreated with hydrocortisone, and in the treated-islets the effect of glucose, epinephrine and dopamine on insulin secretion was examined. Glucose-stimulated insulin secretion in the untreated islets was not changed by the fat diet. Insulin secretion stimulated by hydrocortisone (10(-6)M) in the presence of 2.8 mM glucose was twice higher in the control diet group than in the fat diet group. Pretreatment of the islets with hydrocortisone did not affect glucose-stimulated insulin secretion in the control diet group but remarkably reduced that in the fat diet group. Although the fat diet attenuated the inhibitory effect of catecholamines on insulin secretory response to glucose, pretreatment of the islets with hydrocortisone caused to restore the effect of catecholamines, especially at a low concentration. These results indicate that the combined action of a high fat diet and glucocorticoids may induce modification of alpha-adrenergic receptors in the B-cell.
K Yamaguchi; A Matsuoka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Experimental and clinical endocrinology     Volume:  82     ISSN:  0232-7384     ISO Abbreviation:  Exp. Clin. Endocrinol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302802     Medline TA:  Exp Clin Endocrinol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  IM    
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MeSH Terms
Catecholamines / physiology*
Dietary Fats / administration & dosage*
Dopamine / physiology
Drug Interactions
Epinephrine / physiology
Glucose / physiology
Hydrocortisone / pharmacology*
Insulin / secretion*
Islets of Langerhans / secretion*
Rats, Inbred Strains
Reg. No./Substance:
0/Catecholamines; 0/Dietary Fats; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 50-99-7/Glucose; 51-43-4/Epinephrine

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