Document Detail

Effect of preterm premature rupture of membranes on neurodevelopmental outcome: follow up at two years of age.
MedLine Citation:
PMID:  8534623     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the impact of preterm premature rupture of membranes on the neurodevelopmental outcome of infants, assessed at two years of age. DESIGN: A prospective observational study of surviving preterm infants born after premature rupture of membranes and of infants born after spontaneous preterm labour with intact membranes. The study was carried out in the period 1986 to 1991. SETTING: Pavia, Italy. SUBJECTS: One hundred and forty singleton infants born prematurely after premature rupture of membranes between 24 and 34 weeks of gestation and 120 controls of similar gestational age born after spontaneous preterm labour with intact membranes. MAIN OUTCOME MEASURES: Infant neurodevelopmental outcome at two-year follow up. RESULTS: After adjustment, by logistic analysis for the effect of gestational age and birthweight, infants born after premature rupture of membranes were more likely to have severe neurodevelopmental impairment (spastic tetraplegia and/or Bayley mental developmental index < 71) than controls (adjusted OR 5.75, 95% CI 1.22-27.18). Multivariate analysis of linear trend showed a statistically significant relation of duration of membrane rupture to occurrence of severe intraventricular haemorrhage, cystic periventricular leucomalacia and moderate to severe infant neurodevelopmental impairment. CONCLUSION: Infants born after prolonged premature rupture of membranes are at higher risk of subsequent moderate to severe neurodevelopmental impairment than those born after spontaneous labour with intact membranes.
A Spinillo; E Capuzzo; M Stronati; A Ometto; S Orcesi; E Fazzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  102     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  882-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, IRCCS Policlinico San Matteo, Mondino, Pavia, Italy.
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MeSH Terms
Birth Weight
Cerebral Hemorrhage / epidemiology,  etiology
Child, Preschool
Developmental Disabilities / epidemiology,  etiology*
Fetal Membranes, Premature Rupture* / epidemiology
Gestational Age
Infant, Newborn
Infant, Premature
Italy / epidemiology
Leukomalacia, Periventricular / epidemiology,  etiology
Logistic Models
Prospective Studies
Risk Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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