Document Detail

Effect of preoperative single doses of diclofenac and methylprednisolone on wound healing.
MedLine Citation:
PMID:  7899837     Owner:  NLM     Status:  MEDLINE    
Anti-inflammatory drugs should impair wound healing, which may explain why they have been used to only a limited extent to relieve pain. If they are to have maximal effect they must be started before the operation. In the present study, single doses of the non-steroidal anti-inflammatory agent diclofenac or of diclofenac and the corticosteroid methylprednisolone were given before operation, and the effects on wound healing after operative extraction of third molars were recorded. Patients developed 18 postoperative complications (5%), the most common of which was alveolar osteitis (n = 14), followed by bleeding (n = 3) and infection (n = 1). Pretreatment with diclofenac alone or in combination with methylprednisolone did not result in a notable increase in the incidence of complications as compared to placebo.
T Hyrkäs
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi     Volume:  28     ISSN:  0284-4311     ISO Abbreviation:  Scand J Plast Reconstr Surg Hand Surg     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-21     Completed Date:  1995-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707869     Medline TA:  Scand J Plast Reconstr Surg Hand Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland.
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MeSH Terms
Diclofenac / adverse effects,  therapeutic use*
Dry Socket / epidemiology*
Methylprednisolone / adverse effects,  therapeutic use*
Molar, Third / surgery
Pain, Postoperative / prevention & control*
Tooth Extraction*
Wound Healing / drug effects*
Reg. No./Substance:
15307-86-5/Diclofenac; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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