Document Detail

Effect of preoperative renal function on long-term survival after cardiac surgery.
MedLine Citation:
PMID:  22841165     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The study objective was to investigate the effect of renal failure on intermediate-term survival in cardiac surgery patients.
METHODS: All patients aged 18 years or older undergoing coronary artery bypass grafting, valvular surgery, thoracic aortic surgery, or a combination of these from January 1, 2002 to December 1, 2005 were included. Data were obtained from the cardiac surgery and intensive care databases. Using a matching algorithm, the date of death was obtained from the National Death Index. The simplified Medical Diet for Renal Disease formula was used to calculate the estimated glomerular filtration rate, and the patients were stratified accordingly. An estimation of the effect of the preoperative renal function on the interval to death was determined using Cox regression analysis with and without cubic splines and polynomial regression. The long-term survival was described using the Kaplan-Meier product limit method.
RESULTS: A total of 5297 patients were included in the present study. The vital status of all patients was obtained at a mean of 2.9 years (range, 1-5) postoperatively. The actuarial 1-year survival rate was 96% ± 1%, and the 3-year survival rate was 92% ± 1%. The greatest early mortality occurred in the severe renal dysfunction group; however, the dialysis-dependent renal failure group showed increased mortality over time compared with the other groups. The lowest risk of death (longest interval to death) occurred with an estimated glomerular filtration rate of approximately 90 mL/min/1.73 m(2).
CONCLUSIONS: The results of our study have shown that preoperative renal dysfunction is an independent predictor of long-term mortality in cardiac surgery patients.
Jayesh Dhanani; Daniel V Mullany; John F Fraser
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Publication Detail:
Type:  Journal Article     Date:  2012-07-25
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  146     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2013-08-19     Revised Date:  2014-01-28    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  AIM; IM    
Copyright Information:
Crown Copyright © 2013. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Cardiac Surgical Procedures / mortality*
Heart Diseases / complications*,  surgery*
Middle Aged
Renal Insufficiency, Chronic / complications*
Survival Rate
Time Factors
Comment In:
J Thorac Cardiovasc Surg. 2014 Jan;147(1):539-40   [PMID:  24331913 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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