| Effect of preoperative oral sustained-release morphine sulfate on postoperative morphine requirements in elective spine surgery. | |
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MedLine Citation:
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PMID: 15548244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sustained-release morphine sulfate (SRMS) is a painkiller used in oncology. The purpose of our study was to assess its efficacy on postoperative morphine requirements in elective spine surgery. This was a placebo-controlled, randomized, double-blind study. Adults scheduled for spine surgery under general anesthesia were orally administered SRMS (30 mg) or a placebo 2 h before surgery. Primary endpoint was postoperative cumulated morphine consumption through patient-controlled analgesia (PCA) during the 12 h following extubation. Statistical analysis was performed using a sequential method, the triangular test. The study was stopped after the sixth analysis (51 patients had been included; placebo: 26, SRMS: 25). Age, weight, sex ratio, type of surgery, intra-operative sufentanil consumption, anesthesia duration and time to extubation were similar in the two groups. Morphine consumption through PCA during the 12 h following extubation was significantly lower in the SRMS group (mean +/- SD: 10.5 +/- 7.6 mg) compared with placebo group (15.6 +/- 6.0 mg, P = 0.016, sequential analysis). Corresponding unbiased median estimates were 10.6 and 15.8 mg in SRMS and placebo groups, respectively. Morphine consumption through PCA during the 24 h following extubation was also significantly lower in the SRMS group (15.9 +/- 12.7 mg) compared with the placebo group (23.8 +/- 10.9 mg, P = 0.032). Vigilance, nausea and respiratory rate 3 and 6 h after extubation were similar in the two groups. A preoperative oral administration of SRMS (30 mg) induces a 33% reduction of postoperative morphine requirements in patients scheduled for spine surgery without inducing side effects. |
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Authors:
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Eric Bellissant; Jean-Pierre Estèbe; Véronique Sébille; Claude Ecoffey |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 18 ISSN: 0767-3981 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 709-14 Citation Subset: IM |
Affiliation:
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Centre d'Investigation Clinique INSERM 0203, Unité de Pharmacologie Clinique, Hôpital de Pontchaillou, Université de Rennes 1, 35033 Rennes, France. eric.bellissant@univ-rennes1.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia, Patient-Controlled Analgesics, Opioid / administration & dosage, therapeutic use* Delayed-Action Preparations Double-Blind Method Female Humans Male Middle Aged Morphine / administration & dosage, therapeutic use* Pain, Postoperative / drug therapy* Spine / surgery* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Delayed-Action Preparations; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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