| Effect of preocclusion stenosis severity on heart rate reactions to coronary occlusion. | |
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MedLine Citation:
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PMID: 7977115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autonomic mechanisms may have an important role in the clinical presentation of acute coronary occlusion. This research was designed to evaluate the effect of preocclusion stenosis severity on the immediate autonomic heart rate (HR) responses to a subsequent acute occlusion of the coronary artery. HR and its variability in the time and frequency domains were analyzed in patients with mild to moderate (< or = 85%) (group 1, n = 19) and severe (> 85%) (group 2, n = 18) left anterior descending coronary artery stenosis immediately before and during balloon occlusion (mean 108 seconds). The ranges of nonspecific responses were determined by analyzing HR reactions in a control group (n = 13) with no ischemia during balloon inflation of a totally occluded coronary artery. An abnormal increase in HR variability and/or bradycardia as a sign of vagal activation occurred in 6 patients (32%) in group 1 and in 3 patients (17%) in group 2. A significant decrease in HR variability or tachycardia, or both, was observed in 5 patients (26%) in group 1, but in none of the patients in group 2. Compared with the control group, the balloon occlusion of mild to moderate stenosis caused abnormal HR reactions more often than did occlusion of tight stenosis (58% vs 17%, p < 0.05). Balloon occlusions in group 1 caused chest pain (p < 0.01), ST-segment changes (p < 0.001), and narrowing of pulse pressure (p < 0.05) more often than did occlusions of severe stenoses.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K E Airaksinen; M J Ikäheimo; K J Peuhkurinen; S Yli-Mäyry; M K Linnaluoto; T Serka; H V Huikuri |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 74 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-11-25 Completed Date: 1994-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 864-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Oulu, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Autonomic Nervous System / physiopathology* Blood Pressure / physiology Coronary Angiography Coronary Disease / pathology*, physiopathology, radiography Coronary Vessels / pathology Electrocardiography / methods Female Heart Rate / physiology* Humans Male Middle Aged Signal Processing, Computer-Assisted |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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