| Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood. | |
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MedLine Citation:
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PMID: 21820714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The presence of pets in a home during the prenatal period and during early infancy has been associated with a lower prevalence of allergic sensitization and total IgE levels in middle childhood. No studies have examined the effect of pet exposure in a population-based cohort by using multiple early-life measures of serum total IgE. OBJECTIVE: We sought to examine within-individual longitudinal trends in total IgE levels during early childhood and assess the effect of indoor prenatal pet exposure on those trends. Also, we sought to use a statistical method that was flexible enough to allow and account for unequally spaced study contacts and missing data. METHODS: Using the population-based Wayne County Health, Environment, Allergy and Asthma Longitudinal Study birth cohort (62% African American), we analyzed 1187 infants with 1 to 4 measurements of total IgE collected from birth to 2 years of age. Effects of pet exposure on the shape and trajectory of IgE levels were assessed by using a multilevel longitudinal model, accommodating repeated measures, missing data, and the precise time points of data collection. RESULTS: The best-fit shape to the trajectory of IgE levels was nonlinear, with an accelerated increase before 6 months. Total IgE levels were lower across the entire early-life period when there was prenatal indoor pet exposure (P < .001). This effect was statistically significantly stronger in children delivered by means of cesarean section versus those delivered vaginally (P < .001 and P < .06, respectively) and in those born to non-African American (P < .001) versus African American (P < .3) mothers. CONCLUSION: Pet exposure and delivery mode might be markers of infant exposure to distinct microbiomes. The effect of exposures might vary by race, suggesting a differential effect by ancestry. |
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Authors:
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Suzanne Havstad; Ganesa Wegienka; Edward M Zoratti; Susan V Lynch; Homer A Boushey; Charlotte Nicholas; Dennis R Ownby; Christine Cole Johnson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-05 |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 128 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-03 Completed Date: 2011-11-18 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 880-885.e4 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA. shavsta1@hfhs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans Animals Child, Preschool Environmental Exposure* Female Follow-Up Studies Humans Hypersensitivity* / blood, epidemiology, ethnology, etiology, immunology Immunoglobulin E / blood*, immunology* Infant Infant, Newborn Middle Aged Models, Immunological* Pets* Prevalence Time Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI050681-01A1/AI/NIAID NIH HHS; R01 AI050681-02/AI/NIAID NIH HHS; R01 AI050681-03/AI/NIAID NIH HHS; R01 AI050681-04/AI/NIAID NIH HHS; R01 AI050681-05/AI/NIAID NIH HHS; R01AI051598/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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