Document Detail


Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood.
MedLine Citation:
PMID:  21820714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The presence of pets in a home during the prenatal period and during early infancy has been associated with a lower prevalence of allergic sensitization and total IgE levels in middle childhood. No studies have examined the effect of pet exposure in a population-based cohort by using multiple early-life measures of serum total IgE.
OBJECTIVE: We sought to examine within-individual longitudinal trends in total IgE levels during early childhood and assess the effect of indoor prenatal pet exposure on those trends. Also, we sought to use a statistical method that was flexible enough to allow and account for unequally spaced study contacts and missing data.
METHODS: Using the population-based Wayne County Health, Environment, Allergy and Asthma Longitudinal Study birth cohort (62% African American), we analyzed 1187 infants with 1 to 4 measurements of total IgE collected from birth to 2 years of age. Effects of pet exposure on the shape and trajectory of IgE levels were assessed by using a multilevel longitudinal model, accommodating repeated measures, missing data, and the precise time points of data collection.
RESULTS: The best-fit shape to the trajectory of IgE levels was nonlinear, with an accelerated increase before 6 months. Total IgE levels were lower across the entire early-life period when there was prenatal indoor pet exposure (P < .001). This effect was statistically significantly stronger in children delivered by means of cesarean section versus those delivered vaginally (P < .001 and P < .06, respectively) and in those born to non-African American (P < .001) versus African American (P < .3) mothers.
CONCLUSION: Pet exposure and delivery mode might be markers of infant exposure to distinct microbiomes. The effect of exposures might vary by race, suggesting a differential effect by ancestry.
Authors:
Suzanne Havstad; Ganesa Wegienka; Edward M Zoratti; Susan V Lynch; Homer A Boushey; Charlotte Nicholas; Dennis R Ownby; Christine Cole Johnson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-05
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  128     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-11-18     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  880-885.e4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA. shavsta1@hfhs.org
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Animals
Child, Preschool
Environmental Exposure*
Female
Follow-Up Studies
Humans
Hypersensitivity* / blood,  epidemiology,  ethnology,  etiology,  immunology
Immunoglobulin E / blood*,  immunology*
Infant
Infant, Newborn
Middle Aged
Models, Immunological*
Pets*
Prevalence
Time Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
R01 AI050681-01A1/AI/NIAID NIH HHS; R01 AI050681-02/AI/NIAID NIH HHS; R01 AI050681-03/AI/NIAID NIH HHS; R01 AI050681-04/AI/NIAID NIH HHS; R01 AI050681-05/AI/NIAID NIH HHS; R01AI051598/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E
Comments/Corrections

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