Document Detail

Effect of prenatal hypoxia on heat stress-mediated cardioprotection in adult rat heart.
MedLine Citation:
PMID:  14715507     Owner:  NLM     Status:  MEDLINE    
Fetal programming has profound effects on cardiovascular function in later adult life. We tested the hypothesis that chronic hypoxic exposure during fetal development downregulates endogenous cardioprotective mechanisms in adult rats. Time-dated pregnant rats were divided between normoxic and hypoxic (10.5% O2 from days 15 to 21 of gestation) groups. The male progeny were studied at 2 mo of age. Rats were subjected to heat stress (42 degrees C for 15 min). After 24 h, hearts were excised and subjected to 30 min of global ischemia and 1 h of reperfusion. Prenatal hypoxia did not change adult rat body weight and heart weight, but significantly increased the cross-sectional area of a left ventricular (LV) myocyte. Heat stress significantly improved postischemic recovery of LV function in normoxic control rats, but not in prenatally hypoxic rats. The infarct size in the LV resulting from ischemia-reperfusion was reduced by the heat stress pretreatment in control rats, but not in prenatally hypoxic rats. In accordance, heat stress significantly increased LV myocardial content of heat shock protein 70 only in normoxic control rats. In addition, there was a significant decrease in the LV myocardial content of the PKC-epsilon isoform in prenatally hypoxic rats compared with control rats. We conclude that prenatal hypoxia causes in utero programming of hsp70 gene in the LV, leading to an inhibition of its response to heat stress and a loss of cardioprotection in later adult life.
Guohu Li; Soochan Bae; Lubo Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2004-01-08
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  286     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-09     Completed Date:  2004-05-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1712-9     Citation Subset:  IM    
Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA.
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MeSH Terms
Anoxia / pathology,  physiopathology*
Blotting, Western
Chronic Disease
Fetal Diseases / pathology,  physiopathology*
Heart / physiopathology*
Heat-Shock Proteins / metabolism
Hot Temperature*
Myocardial Infarction / pathology
Myocardial Ischemia / physiopathology
Myocardial Reperfusion Injury / physiopathology
Myocardium / pathology
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Stress, Physiological / physiopathology*
Ventricular Function, Left
Grant Support
Reg. No./Substance:
0/Heat-Shock Proteins

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