| Effect of prenatal glucocorticoid treatment on size at birth among infants born at term gestation. | |
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MedLine Citation:
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PMID: 19587690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether prenatal treatment with a single course of glucocorticoids (GCs) affects size at birth among full-term infants independent of fetal size before GC administration or exposure to preterm labor (PTL). STUDY DESIGN: In all, 105 full-term infants were recruited into three study groups (30 GC treated; 60 controls matched for gestational age (GA) at birth and sex; and 15 PTL controls without GC exposure). Size of the infants was estimated before treatment using two-dimensional (2D) ultrasound and by direct measurement at birth. RESULTS: Length, weight and head circumference at birth were smaller among GC-treated infants compared with matched controls (P's<0.01), although fetal size did not differ before treatment (P's>0.2). Exposure to PTL did not account for this effect. CONCLUSIONS: Prenatal treatment with a single course of GCs was associated with a reduction in size at birth among infants born at term gestation. This effect cannot be explained by differences in fetal size before treatment or exposure to PTL. |
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Authors:
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E P Davis; F Waffarn; C Uy; C J Hobel; L M Glynn; C A Sandman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-07-09 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 29 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2010-02-01 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 731-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Human Behavior, University of California, Irvine, Orange, CA 92677, USA. edavis@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / administration & dosage, adverse effects* Betamethasone / administration & dosage, adverse effects* Birth Weight / drug effects* Female Fetal Development / drug effects Humans Infant, Newborn Male Obstetric Labor, Premature / drug therapy Pregnancy Respiratory Distress Syndrome, Newborn / prevention & control* Ultrasonography, Prenatal |
| Grant Support | |
ID/Acronym/Agency:
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HD-50662/HD/NICHD NIH HHS; NS-41298/NS/NINDS NIH HHS; R01 HD050662-02/HD/NICHD NIH HHS; R01 HD065823/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 378-44-9/Betamethasone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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