| Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice. | |
| | |
MedLine Citation:
|
PMID: 18938223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Diesel exhaust (DE) is composed of particles and gaseous compounds. It has been reported that DE causes pulmonary and cardiovascular disease. We have previously reported that fetal exposure to DE had deleterious effects to the reproductive system of mice offspring. However, there is still little known about the effects of prenatal exposure to DE to the central nervous system (CNS). In the present study, we found that prenatal exposure to DE induced reduction of locomotion, furthermore, dopamine (DA) turnover was significantly decreased in the striatum and nucleus accumbens. These results suggest that prenatal exposure to DE has an effect on the CNS. Hypolocomotion could be due to a decrease in DA turnover associated with DA nervous system abnormality. The present study provides the possibility that maternally inhaled DE might influence the development of central dopaminergic system and result in behavior disorder. |
| | |
Authors:
|
Satoshi Yokota; Keisuke Mizuo; Nozomu Moriya; Shigeru Oshio; Isamu Sugawara; Ken Takeda |
Related Documents
:
|
10715563 - Repeated prenatal cocaine increases met-enkephalin immunoreactivity in respiratory-rela... 15706793 - Alcohol and the hormonal control of lactation. 22245773 - Normal pregnancy: mechanisms underlying the paradox of a ouabain-resistant state with e... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-14 |
Journal Detail:
|
Title: Neuroscience letters Volume: 449 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-01 Completed Date: 2009-04-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 38-41 Citation Subset: IM |
Affiliation:
|
Department of Hygiene Chemistry, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3,4-Dihydroxyphenylacetic Acid
/
metabolism Animals Brain / metabolism Circadian Rhythm / physiology Dopamine / metabolism* Female Homovanillic Acid / metabolism Male Mice Mice, Inbred ICR Motor Activity / physiology Pregnancy Prenatal Exposure Delayed Effects / chemically induced*, metabolism*, pathology, physiopathology Time Factors Vehicle Emissions* |
| Chemical | |
Reg. No./Substance:
|
0/Vehicle Emissions; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.
Next Document: Differential effects of neonatal norepinephrine lesions on immediate early gene expression in develo...