Document Detail

Effect of prenatal T4 treatment in neonatal morbidity: preliminary findings.
MedLine Citation:
PMID:  9160396     Owner:  NLM     Status:  MEDLINE    
We report our experience with the use of intra-amniotic thyroxine to accelerate fetal maturation in preterm delivered infants. One hundred and fourteen infants who had received 500 micrograms of thyroxine weekly prenatally until an L/S ratio greater or equal to 2.0 was achieved, were compared to 113 premature infants who had not been given thyroxine or steroids prenatally. After stratification by weight, the relative incidence of respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC) and intraventricular hemorrhage (IVH) were compared. A decrease in the incidence of RDS was observed in the infants with birth weight between 1000 and 1500 g who had received more than one dose of intra-amniotic thyroxine. No difference in the incidence of RDS was observed in infants with birth weight of less than 1000 g or over 1500 g. One dose of thyroxine had no effect in decreasing the incidence of RDS, PDA, NEC, and IVH in any of the groups. We conclude intra-amniotic thyroxine seems to decreases the incidence of RDS in very low birth weight infants.
G Reyes; J Romaguera; R Zapata; M Valcarcel; K Adamsons
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Puerto Rico health sciences journal     Volume:  16     ISSN:  0738-0658     ISO Abbreviation:  P R Health Sci J     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8303541     Medline TA:  P R Health Sci J     Country:  PUERTO RICO    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Department of Pediatrics, University of Puerto Rico, School of Medicine, USA.
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MeSH Terms
Cerebral Hemorrhage / epidemiology,  prevention & control*
Drug Evaluation
Ductus Arteriosus, Patent / epidemiology,  prevention & control*
Enterocolitis, Pseudomembranous / epidemiology,  prevention & control*
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Prenatal Care*
Respiratory Distress Syndrome, Newborn / epidemiology,  prevention & control*
Thyroxine / administration & dosage*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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