Document Detail

Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial.
MedLine Citation:
PMID:  23321224     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of this study was to compare 2 kinds of anti-inflammatory medicines (ie, dexamethasone and ibuprofen) with a placebo according to their effects on the success rates of an inferior alveolar nerve block (IANB) for the endodontic treatment of mandibular molars with irreversible pulpitis.
METHODS: A total of 165 patients were divided into 3 groups of 55 patients each and were given a capsule of the same color and size (ie, a placebo of lactose powder, 400 mg ibuprofen, or 0.5 mg dexamethasone). One hour after the oral administration of the capsules, all the patients received a standard IANB. In patients with a successful IANB, the teeth were examined with a cold pulp test. Patients were asked to assess their pain using the visual analog scale. Then, endodontic access cavity preparation was initiated. In case of pain during the treatment, the patients were asked to rate the pain on the visual analog scale. Success was defined as no or mild pain during treatment. The chi-square test and analysis of variance were used to compare qualitative and quantitative data among the groups.
RESULTS: No significant differences were found regarding the sex of the patients in the 3 groups (P > .05). The dexamethasone group showed significantly higher success rates compared with the placebo group (P = .001). There were no significant differences between the ibuprofen and placebo groups (P = .055) or the dexamethasone and ibuprofen groups (P = .34).
CONCLUSIONS: Premedication with dexamethasone increased the success rate of an IANB in mandibular molars with asymptomatic irreversible pulpitis.
Shahriar Shahi; Hadi Mokhtari; Saeed Rahimi; Hamid Reza Yavari; Shima Narimani; Majid Abdolrahimi; Saeed Nezafati
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2012-11-17
Journal Detail:
Title:  Journal of endodontics     Volume:  39     ISSN:  1878-3554     ISO Abbreviation:  J Endod     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2014-01-09     Revised Date:  2014-08-26    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-2     Citation Subset:  D    
Copyright Information:
Copyright © 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Anesthetics, Local / administration & dosage
Anti-Inflammatory Agents / therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Asymptomatic Diseases
Dental Pulp Test
Dexamethasone / therapeutic use*
Double-Blind Method
Follow-Up Studies
Ibuprofen / therapeutic use*
Lidocaine / administration & dosage
Lip / innervation
Mandibular Nerve* / drug effects
Molar / pathology
Nerve Block / methods*
Pain Measurement
Prospective Studies
Pulpitis / physiopathology*,  therapy
Root Canal Preparation / methods
Reg. No./Substance:
0/Anesthetics, Local; 0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Placebos; 7S5I7G3JQL/Dexamethasone; 98PI200987/Lidocaine; WK2XYI10QM/Ibuprofen
Comment In:
J Evid Based Dent Pract. 2013 Sep;13(3):102-3   [PMID:  24011005 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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