Document Detail


Effect of pregnancy on serum alanine concentration in normal and genetically diabetic mice.
MedLine Citation:
PMID:  1002107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum alanine concentration was determined in nonpregnant and pregnant normal control Swiss albino (SA) and genetically diabetic KK mice. The serum alanine levels were significantly lower in nonpregnant KK than in nonpregnant SA mice. Fasting elicited hypoglycemia, hypoinsulinemia and hypoalaninemia in both groups of pregnant mice. Oral administration of alanine in nonpregnant and pregnant mice resulted in a significant rise in blood sugar levels within 15 min in both groups. However, the initial blood sugar response to oral alanine was greater in pregnant than in nonpregnant mice. This increase in blood sugar response to exogenous alanine appears to be mediated by glucagon. The data suggest that pregnancy elicits hypoglycemia, hypoinsulinemia and hypoalaninemia in both nondiabetic and diabetic mice.
Authors:
A S Reddi; W Oppermann; L H Strugatz; H S Cole; R A Camerini-Davolos
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  8     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-02-24     Completed Date:  1977-02-24     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  478-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine / blood*,  pharmacology
Animals
Blood Glucose / metabolism
Diabetes Mellitus / blood*
Fasting
Female
Pregnancy
Pregnancy in Diabetics / blood*
Pregnancy, Animal*
Rats
Chemical
Reg. No./Substance:
0/Blood Glucose; 56-41-7/Alanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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