Document Detail

Effect of pregnancy on renal function in amyloidosis of familial Mediterranean fever.
MedLine Citation:
PMID:  8164208     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effect of pregnancy on kidney function in patients with familial Mediterranean fever (FMF) with amyloidosis. METHODS: A retrospective analysis relating kidney function at term to kidney function at conception and to blood pressure and colchicine treatment before and during pregnancy in 17 patients with 29 pregnancies found among more than 3000 patient files in our FMF clinic. RESULTS: Following pregnancy, 7 patients (24% of pregnancies) experienced a decline in renal function. Urine protein > or = 2 g/24 h at conception was present in all pregnancies which sustained deterioration in contrast to 6 of 22 which did not (p < 0.001). Serum creatinine > or = 1.5 mg/dl at conception was present in 3 patients, all of whom experienced deterioration of renal function during pregnancy (p < 0.01). Neither colchicine dose nor elevated blood pressure correlated with status of renal function at term. CONCLUSION: Our findings suggest a possible deleterious effect of pregnancy on amyloid nephropathy and that this effect may be associated with more advanced renal disease at conception.
A Livneh; S Cabili; D Zemer; O Rabinovitch; M Pras
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  20     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-05-26     Completed Date:  1994-05-26     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1519-23     Citation Subset:  IM    
Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Amyloidosis / drug therapy,  etiology*,  physiopathology*
Colchicine / therapeutic use
Familial Mediterranean Fever / complications*
Kidney / physiopathology*
Kidney Failure, Chronic / etiology
Pregnancy Complications*
Pregnancy Outcome
Reg. No./Substance:

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