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THE EFFECT OF PREGNANCY AND POSTPARTUM RECOVERY ON THE VISCOELASTIC BEHAVIOR OF THE RAT CERVIX.
MedLine Citation:
PMID:  23125473     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective of this study was to elucidate the normal functional adaptations of the cervix in pregnancy. Utilizing a Long-Evans rodent model, the cervix was divided into distal and proximal portions for virgin, mid-pregnant, and four weeks postpartum animals. The quasi-linear viscoelastic theory describes the elastic and viscous behavior of the cervix. A hydroxyproline assay was used to measure collagen content. The nonlinearity of the elastic response significantly increased throughout the entire cervix during pregnancy when compared to virgin samples (p < 0.05) and was similar to virgin samples postpartum. All viscous behavior, except for the short-term relaxation of the proximal cervix, significantly differed for pregnant specimens (p < 0.05) and remained similar to pregnant samples postpartum. Collagen content was found to increase by mid-pregnancy only in the proximal cervix when compared to virgin. Distal and proximal portions, however, were found to differ in collagen content at all time points (p < 0.05). This study finds that the cervix becomes elastically stiffer with increasing strain and exhibits increased viscous behavior during pregnancy, with incomplete recovery postpartum. These alterations allow for quick dissipation of loads, and are likely related to altered matrix organization and porosity reported by others.
Authors:
William R Barone; Andrew J Feola; Pamela A Moalli; Steven D Abramowitch
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of mechanics in medicine and biology     Volume:  12     ISSN:  0219-5194     ISO Abbreviation:  J Mech Med Biol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134377     Medline TA:  J Mech Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  12500091-125000917     Citation Subset:  -    
Affiliation:
Musculoskeletal Research Center, Department of Bioengineering University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh Pennsylvania 15219, USA.
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