Document Detail

Effect of pregnancy of cellular inflammation.
MedLine Citation:
PMID:  7150504     Owner:  NLM     Status:  MEDLINE    
Pregnancy inhibits macrophage accumulation within the peritoneal cavity of Wistar rats when inflammation is induced by phytohaemagglutinin (PHA). The inhibition of macrophages was considerably greater than that of polymorphonuclear leucocytes (PMNs) induced by sodium caseinate. Pregnancy did not significantly alter macrophage accumulation to PHA injected into the pleural space or to nitrocellulose filters placed s.c. Cell-free homogenates prepared from the products of conception, but not normal liver, contained an anti-flammatory factor which, when injected i.v., inhibited macrophage accumulation to peritoneal but not to pleural or s.c. irritants. The responsible anti-inflammatory factor was identified as a peptide of mol. wt less than 1000.
S J Normann; M Schardt; E Sorkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  63     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  432-7     Citation Subset:  IM    
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MeSH Terms
Ascitic Fluid / cytology
Cell-Free System
Embryo, Mammalian
Leukocytes / drug effects
Macrophage Activation
Macrophages / drug effects*
Peritoneal Cavity / pathology
Peritonitis / chemically induced,  prevention & control*
Phytohemagglutinins / pharmacology*
Grant Support
CA 22517-05/CA/NCI NIH HHS
Reg. No./Substance:

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