| Effect of pregnancy of cellular inflammation. | |
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MedLine Citation:
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PMID: 7150504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy inhibits macrophage accumulation within the peritoneal cavity of Wistar rats when inflammation is induced by phytohaemagglutinin (PHA). The inhibition of macrophages was considerably greater than that of polymorphonuclear leucocytes (PMNs) induced by sodium caseinate. Pregnancy did not significantly alter macrophage accumulation to PHA injected into the pleural space or to nitrocellulose filters placed s.c. Cell-free homogenates prepared from the products of conception, but not normal liver, contained an anti-flammatory factor which, when injected i.v., inhibited macrophage accumulation to peritoneal but not to pleural or s.c. irritants. The responsible anti-inflammatory factor was identified as a peptide of mol. wt less than 1000. |
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Authors:
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S J Normann; M Schardt; E Sorkin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: British journal of experimental pathology Volume: 63 ISSN: 0007-1021 ISO Abbreviation: Br J Exp Pathol Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0372543 Medline TA: Br J Exp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 432-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / cytology Cell-Free System Embryo, Mammalian Female Leukocytes / drug effects Macrophage Activation Macrophages / drug effects* Peritoneal Cavity / pathology Peritonitis / chemically induced, prevention & control* Phytohemagglutinins / pharmacology* Pregnancy* Rats |
| Grant Support | |
ID/Acronym/Agency:
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CA 22517-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phytohemagglutinins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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