Document Detail

Effect of pregnancy on bone mineral density in healthy women.
MedLine Citation:
PMID:  11832786     Owner:  NLM     Status:  MEDLINE    
Despite numerous studies and case reports of changes in bone mineral density (BMD) during pregnancy, the postpartum, and lactation, controversy exists regarding the time course of BMD changes and recovery to baseline levels. The degree to which pregnancy affects BMD long-term remains unclear. Several influencing factors, including breast-feeding, length of amenorrhea after pregnancy, and parity, have been studied with respect to changes in BMD in healthy women. We conducted the first systematic review of its kind on this topic and evaluated the 23 identified citations according to the U.S. Preventive Services Task Force rating scale. Six studies qualified as Level II-2, 12 were Level II-3, and 5 were Level III. There seems to be good evidence that calcium is mobilized from the maternal skeleton to that of the developing fetus during pregnancy. However, the eventual return of BMD to prepregnancy values suggests that maternal bone loss may not be permanent. Results from the studies that specifically evaluated the effect of lactation on BMD were varied, ranging from a decrease in BMD to no change. Of the studies that evaluated the effect of parity on BMD, none found an association linking a greater number of pregnancies to greater decreases in BMD. Pregnancy-associated osteoporosis seems to be uncommon, based on the limited published reports. Overall, no long-term adverse clinical effects have been noted in healthy women who had at least one ongoing pregnancy, despite the good evidence that some bone loss does occur soon after delivery. Additional longitudinal studies need to be undertaken to provide more definitive information on the effects of pregnancy on BMD and risk of osteoporosis later in life.
Mary H H Ensom; Pamela Y Liu; Mary D Stephenson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrical & gynecological survey     Volume:  57     ISSN:  0029-7828     ISO Abbreviation:  Obstet Gynecol Surv     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401007     Medline TA:  Obstet Gynecol Surv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-111     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, University of British Columbia, Canada.
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MeSH Terms
Bone Density*
Calcium / metabolism
Case-Control Studies
Controlled Clinical Trials as Topic
Cross-Sectional Studies
Longitudinal Studies
Pregnancy / physiology*
Randomized Controlled Trials as Topic
Reg. No./Substance:

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