Document Detail

Effect of pregnancy and birth on the course of myasthenia gravis before or after transsternal radical thymectomy.
MedLine Citation:
PMID:  16386922     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Myasthenia gravis (MG) affects women at childbearing age. Therefore, the question arises if these patients should become pregnant and if thymectomy has a positive effect on the course of MG in pregnant patients. METHODS: Fifteen pregnancies had been followed retrospectively. All patients underwent transsternal radical thymectomy for MG. The course of MG in the period before, during, and after the pregnancy was scored according to Ossermann's classification. The effect of thymectomy on delivery and on the newborns was evaluated. RESULTS: Patients were divided in two groups: pregnancies before (group I, n=8) and after (group II, n=7) thymectomy. During pregnancy, in group I, one deterioration was observed and in seven patients the disease was unchanged. In group II, one deterioration, five unchanged courses, and one improvement were observed. In the postpartum period, in group I, seven patients did not change and one improved. In group II, two deteriorations, three unchanged courses, and two improvements were observed. Before pregnancy, group II patients were in a better Ossermann stage in comparison with those in group I. Eight of the 12 deliveries were spontaneous (three abortus). Myasthenic symptoms were observed in two newborns in group I. CONCLUSION: Our data suggest that MG is not prohibitive to have children. The course of MG after transsternal radical thymectomy is often ameliorated. A better MG-stage, reached after thymectomy, before pregnancy seems to be correlated with a better course during pregnancy.
Thierry Christophe Roth; Janine Raths; Gianluca Carboni; Kai Rösler; Ralph Alexander Schmid
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  29     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Division of General Thoracic Surgery, University Hospital, 3010 Berne, Switzerland.
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MeSH Terms
Breast Feeding
Delivery, Obstetric
Follow-Up Studies
Infant, Newborn
Middle Aged
Myasthenia Gravis / physiopathology,  surgery*
Postpartum Period
Pregnancy Complications / physiopathology,  surgery*
Pregnancy Outcome
Remission Induction
Retrospective Studies
Comment In:
Eur J Cardiothorac Surg. 2006 Aug;30(2):411-2; author reply 412   [PMID:  16828298 ]

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