| Effect of preeclampsia on mortality, intraventricular hemorrhage, and need for mechanical ventilation in very low-birth-weight infants. | |
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MedLine Citation:
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PMID: 9722059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infants born to mothers with preeclampsia have been shown to have a reduction in intraventricular hemorrhage (IVH). The objective of this article is to investigate the relationship between preeclampsia, IVH, neonatal mortality, mechanical ventilation, and other potential confounding variables such as neutropenia and magnesium sulfate. Methods of research include review of infants <1500 g admitted to a single level III neonatal intensive care unit (NICU), n=356. Infants born to mothers with preeclampsia were compared to those without maternal preeclampsia by univariate and multivariate analysis. Overall, 52 mothers were diagnosed with preeclampsia. After multivariate modeling, preeclampsia was not associated with a decrease in mechanical ventilation (odds ratio 0.5, 95% CI 0.2-1.3), IVH (odds ratio 0.5, 0.1-1.9) or mortality (odds ratio 0.6, 0.2-1.9). In our population, after controlling for multiple confounding variables, including MgSO4, neutropenia and thrombocytopenia, there was no difference in the odds of mortality, IVH, or requirement for mechanical ventilation in infants born to mothers with preeclampsia as compared to infants born to mothers without preeclampsia. |
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Authors:
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D A Paul; J Kepler; K H Leef; A Siscione; C Palmer; J L Stefano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 15 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-11-10 Completed Date: 1998-11-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 381-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Christiana Care Health Systems, Newark, Delaware 19718, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Cerebral Hemorrhage / etiology*, mortality* Cerebral Ventricles Cysts / etiology Female Humans Incidence Infant, Newborn Infant, Newborn, Diseases / etiology*, mortality* Infant, Very Low Birth Weight* Leukomalacia, Periventricular / etiology, mortality Logistic Models Male Odds Ratio Pre-Eclampsia / complications* Pregnancy Respiration, Artificial* |
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