| Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. | |
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MedLine Citation:
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PMID: 18937939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of pregestational metformin administration on abortion risk in polycystic ovary syndrome (PCOS) patients. DESIGN: Systematic review and meta-analysis. SETTING: Academic Department of Obstetrics and Gynecology in Italy. PATIENT(S): Women affected by PCOS receiving pregestational metformin. INTERVENTION(S): Systematic review of randomized controlled trials (RCTs) published up to June 2008 and subsequent meta-analysis. MAIN OUTCOME MEASURE(S): Abortion rate. RESULT(S): Seventeen RCTs were included in the final analysis. Overall, no effect of the metformin administration was detected on the abortion risk. No statistically significant effect of metformin on the abortion risk was observed in any comparison when subgrouping the RCTs according to received treatment. CONCLUSION(S): Metformin has no effect on the abortion risk in PCOS patients when administered before pregnancy. |
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Authors:
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Stefano Palomba; Angela Falbo; Francesco Orio; Fulvio Zullo |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Review Date: 2008-10-19 |
Journal Detail:
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Title: Fertility and sterility Volume: 92 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2009-11-23 Revised Date: 2010-02-22 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1646-58 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, University Magna Graecia of Catanzaro, Italy. stefanopalomba@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology* Adult Algorithms Female Humans Hypoglycemic Agents / adverse effects, therapeutic use Metformin / administration & dosage, adverse effects*, therapeutic use* Ovulation Induction / methods Polycystic Ovary Syndrome / drug therapy*, epidemiology Preconception Injuries Pregnancy Prenatal Exposure Delayed Effects / epidemiology, etiology* Randomized Controlled Trials as Topic / statistics & numerical data* Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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