| Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity. | |
| | |
MedLine Citation:
|
PMID: 17054582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The aim of the present study was to test a prebiotic-phytotherapic compound in an experimental model of oral allergenicity. METHODS: Antigen-specific immunoglobulin E (IgE) elevated mice were prepared by injecting them intraperitoneally with 10 microg of ovalbumin. Subsequently, the mice were exposed to ovalbumin solution intranasally and blood samples were obtained on weekly intervals for 4 weeks to measure serum-ovalbumin-specific IgE and total immunoglobulin G. Mice with high titers of ovalbumin-IgE were intragastrically administered with 0.3 mL of phosphate buffered solution containing either 20 mg of ovalbumin, the same solution with 5 mL of milk, or 20 mg milk added to prebiotic-phytocompound. RESULTS: Ovalbumin administration caused a significant increase of plasma ovalbumin concentration in sensitized mice while prebiotic-phytocompound-supplemented mice showed a significantly reduced peak value (P < 0.05). Prebiotic-phytocompound added to milk exerted a significant effect in lowering the ovalbumin-IgE level and the total immunoglobulin G level as compared to control plain milk (P < 0.01). CONCLUSION: This study provides a rationale basis for a feasible non-pharmacological therapeutic strategy in food allergen hypersensitivity syndromes. |
| | |
Authors:
|
Yussef Metugriachuk; Juichiro Tsuchiya; Francesco Marotta; Sam Kawakita; Ruichi Okura; Olivia Kuroi; Emilio Minelli |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chinese journal of digestive diseases Volume: 7 ISSN: 1443-9611 ISO Abbreviation: Chin J Dig Dis Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-10-23 Completed Date: 2007-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101088612 Medline TA: Chin J Dig Dis Country: Australia |
Other Details:
|
Languages: eng Pagination: 206-10 Citation Subset: IM |
Affiliation:
|
Tsuchiya Medical Corporation Hospital, University of Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Food Hypersensitivity / drug therapy*, immunology Immunoglobulin G / blood Lactobacillus* Male Mice Milk Ovalbumin / adverse effects*, blood, immunology Phytotherapy Probiotics / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population w...
Next Document: Alternation of substance P-containing neural pathways in a rat model of irritable bowel syndrome wit...