| Effect of pre-treatment with transdermal glyceryl trinitrate on myocardial ischaemia during coronary angioplasty. | |
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MedLine Citation:
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PMID: 9014793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In the light of the reported inconsistent anti-ischaemic and antianginal effects of transdermal glyceryl trinitrate, its efficacy and influence on the effects of intracoronary glyceryl trinitrate were examined during coronary angioplasty, which provides a model of controlled, reversible ischaemia. DESIGN: Double blind, randomised study of the effect of transdermal and intracoronary glyceryl trinitrate on ischaemia during coronary angioplasty. PATIENTS: 40 patients with isolated severe stenosis of the left anterior descending coronary artery. INTERVENTIONS: Patients were randomised (double blind) to transdermal glyceryl trinitrate (10 mg per day) and placebo, starting four to six hours before angioplasty. After 4 one-minute balloon inflations intracoronary glyceryl trinitrate was injected (0.2 mg) and then 4 further one-minute inflations were performed. MAIN OUTCOME MEASURES: The time to angina and the time to > 0.2 mV ST shift on surface electrocardiogram (ECG) or intracoronary ECG during the individual inflations. RESULTS: These times did not significantly differ during initial inflations between transdermal glyceryl trinitrate (27 (11), 25 (9), and 19 (9) s, respectively) and placebo (34 (11), 30 (8), and 21 (7) s. After intracoronary glyceryl trinitrate, they were significantly prolonged compared with the initial values, without differences between patients with transdermal glyceryl trinitrate (37 (10), 30 (8), and 23 (8) s, respectively) or placebo (39 (15), 36 (11), and 28 (12) s). Ischaemic preconditioning was not seen. CONCLUSIONS: Transdermal glyceryl trinitrate (10 mg per day), unlike intracoronary glyceryl trinitrate, did not alleviate the myocardial ischaemia produced by balloon inflation during coronary angioplasty. |
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Authors:
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S Ramamurthy; V Mehan; U Kaufmann; V Verin; T F Lüscher; B Meier |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 76 ISSN: 1355-6037 ISO Abbreviation: Heart Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-02-18 Completed Date: 1997-02-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 471-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University Hospital, Bern, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Angioplasty, Transluminal, Percutaneous Coronary* Coronary Disease / physiopathology, surgery* Coronary Vessels Double-Blind Method Electrocardiography Female Humans Injections, Intra-Arterial Intraoperative Complications / prevention & control* Male Middle Aged Myocardial Ischemia / physiopathology, prevention & control* Nitroglycerin / administration & dosage*, therapeutic use Premedication* |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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