| Effect of pre-germination time of brown rice on serum cholesterol levels of hypercholesterolaemic rats. | |
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MedLine Citation:
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PMID: 20355038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Brown rice is unpolished rice with immeasurable benefits for human health. Brown rice (BR) and pre-germinated brown rice (PGBR) are known to contain various functional compounds such as gamma-oryzanol, dietary fibre and gamma-aminobutyric acid (GABA). In the present study, the experimental diets containing BR and PGBR (24, 48 h pre-germination) were used to investigate the influence of pre-germination time of brown rice on blood cholesterol in Sprague-Dawley male rats. RESULTS: Hypercholesterolaemia and elevation of LDL-cholesterol were successfully ameliorated by the experimental diets containing BR and PGBR (24 and 48 h pre-germination). As compared to the control sample, the pre-germination time had a significant (P < 0.05) effect on blood cholesterol of Sprague-Dawley male rats. It was also found that the significantly (P < 0.05) better effect on lipid profile of hypercholesterolaemic rats was observed by prolonging the pre-germination time. As compared to non-germinated brown rice, the germinated brown rice showed the higher cardio-protective effect on hypercholesterolaemic Sprague-Dawley male rats. CONCLUSION: The present study suggests that the changes of blood cholesterol can be mainly modulated by using the PGBR rather than BR. The prolonging of pre-germination time led to an increase in the bioactive components, thereby providing a more efficient functional diet affecting the high blood cholesterol. This study suggests that PGBR can be used instead of BR and polished rice in the human diet. |
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Authors:
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Shahin Roohinejad; Alireza Omidizadeh; Hamed Mirhosseini; Nazamid Saari; Shuhaimi Mustafa; Rokiah Mohd Yusof; Anis Shobirin Meor Hussin; Azizah Hamid; Mohd Yazid Abd Manap |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the science of food and agriculture Volume: 90 ISSN: 1097-0010 ISO Abbreviation: J. Sci. Food Agric. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376334 Medline TA: J Sci Food Agric Country: England |
Other Details:
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Languages: eng Pagination: 245-51 Citation Subset: IM |
Copyright Information:
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(c) 2009 Society of Chemical Industry. |
Affiliation:
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Department of Food Technology, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / blood* Cholesterol, LDL / blood Dietary Fats / administration & dosage Dietary Fiber / metabolism Food Handling Functional Food* Germination* Hypercholesterolemia / diet therapy* Lipids / blood Male Oryza sativa / chemistry*, growth & development Phenylpropionates / metabolism Rats Rats, Sprague-Dawley gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Dietary Fats; 0/Lipids; 0/Phenylpropionates; 11042-64-1/gamma-oryzanol; 56-12-2/gamma-Aminobutyric Acid; 57-88-5/Cholesterol |
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