Document Detail

Effect of pre-emptive gabapentin on postoperative pain following lower extremity orthopaedic surgery under spinal anaesthesia.
MedLine Citation:
PMID:  22159930     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Gabapentin has demonstrated efficacy in clinical trials as a pre-emptive analgesic and in acute postoperative pain management. However, our experience with the drug is still limited. The present study was conducted in order to evaluate the effect of gabapentin on reduction of postoperative pain in the first 24 hours after internal fixation of the tibia under spinal anaesthesia.
METHODS: In a double-blind, randomised controlled clinical trial, 64 American Society of Anesthesiologists Class I or II patients, who underwent internal fixation of the tibia, were administered 300 mg of gabapentin or a placebo two hours before surgery. The postoperative pain was assessed using Visual Analogue Scale two, 12 and 24 hours after surgery. The time from the end of surgery until the first bolus dose of morphine on demand (pain score > 4) and the total morphine requirement were recorded. Patients were also asked about the possible side effects of gabapentin.
RESULTS: The pain score was significantly lower in the gabapentin group at two hours post surgery (p-value is 0.004), while the scores at 12 and 24 hours post surgery were not significantly different between the two groups. No side effect of gabapentin was observed.
CONCLUSION: Pre-emptive use of gabapentin 300 mg orally significantly decreases postoperative pain two hours after surgery.
M Panah Khahi; A A Yaghooti; S H Marashi; A Nadjafi
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Singapore medical journal     Volume:  52     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-04-17     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  879-82     Citation Subset:  IM    
Department of Anaesthesiology, Critical Care and Pain, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Amines / pharmacology*,  therapeutic use
Anesthesia, Spinal / methods*
Anesthesiology / methods
Cyclohexanecarboxylic Acids / pharmacology*,  therapeutic use
Double-Blind Method
Fracture Fixation, Internal / methods
Morphine / therapeutic use
Orthopedics / methods*
Pain / drug therapy
Pain, Postoperative
Tibia / surgery
Time Factors
Treatment Outcome
gamma-Aminobutyric Acid / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Amines; 0/Cyclohexanecarboxylic Acids; 0/Placebos; 56-12-2/gamma-Aminobutyric Acid; 57-27-2/Morphine; 6CW7F3G59X/gabapentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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