| Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats. | |
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MedLine Citation:
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PMID: 21318567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: Relapse to alcohol use during abstinence or maladaptive eating habits during dieting is often provoked by stress. The anxiogenic drug yohimbine, which causes stress-like responses in humans and non-humans, reliably reinstates alcohol and food seeking in a rat relapse model. Yohimibine is a prototypical alpha-2 adrenoceptor antagonist, but results from studies on noradrenaline's role in yohimbine-induced reinstatement of drug and food seeking are inconclusive. Here, we further addressed this issue by studying the effect of the alpha-1 adrenoceptor antagonist prazosin and the alpha-2 adrenoceptor agonist guanfacine on yohimbine-induced reinstatement. METHODS: In exp. 1, we trained rats to self-administer alcohol (12% w/v, 1 h/day), and after extinction of alcohol-reinforced lever pressing, we tested prazosin's (0.5, 1.0, and 2.0 mg/kg, i.p.) or guanfacine's (0.125, 0.25, and 0.5 mg/kg, i.p.) effect on yohimbine (1.25 mg/kg, i.p.)-induced reinstatement; we also examined prazosin's effect on intermittent-footshock-stress-induced reinstatement. In exp. 2, we trained food-restricted rats to self-administer 45 mg food pellets and first examined prazosin's or guanfacine's effects on food-reinforced responding, and then, after extinction of lever presses, on yohimbine-induced reinstatement. RESULTS: Prazosin (0.5-2.0 mg/kg) blocked yohimbine-induced reinstatement of food and alcohol seeking, as well as footshock-induced reinstatement of alcohol seeking. Guanfacine attenuated yohimbine-induced reinstatement of alcohol seeking at the highest dose (0.5 mg/kg), but its effect on yohimbine-induced reinstatement of food seeking was not significant. Neither prazosin nor guanfacine affected high-rate food-reinforced responding. CONCLUSIONS: Results demonstrate an important role of postsynaptic alpha-1 adrenoceptors in stress-induced reinstatement of alcohol and food seeking. |
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Authors:
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A D Lê; Douglas Funk; Walter Juzytsch; Kathleen Coen; Brittany M Navarre; Carlo Cifani; Yavin Shaham |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2011-02-12 |
Journal Detail:
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Title: Psychopharmacology Volume: 218 ISSN: 1432-2072 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-12 Completed Date: 2012-02-08 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 89-99 Citation Subset: IM |
Affiliation:
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Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada. Anh_le@camh.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-1 Receptor Antagonists
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administration & dosage,
pharmacology Adrenergic alpha-2 Receptor Agonists / administration & dosage, pharmacology Adrenergic alpha-2 Receptor Antagonists / pharmacology Animals Conditioning, Operant / drug effects Dose-Response Relationship, Drug Ethanol / administration & dosage* Feeding Behavior / drug effects* Guanfacine / administration & dosage, pharmacology* Male Prazosin / administration & dosage, pharmacology* Rats Rats, Long-Evans Rats, Wistar Recurrence / prevention & control Self Administration Stress, Psychological Yohimbine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AA13108/AA/NIAAA NIH HHS; R01 AA013108-09/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-1 Receptor Antagonists; 0/Adrenergic alpha-2 Receptor Agonists; 0/Adrenergic alpha-2 Receptor Antagonists; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 29110-47-2/Guanfacine; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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