Document Detail

Effect of pravastatin in treatment of hypercholesterolemia in non-insulin-dependent diabetes patients.
MedLine Citation:
PMID:  9078811     Owner:  NLM     Status:  MEDLINE    
To evaluate the efficacy of pravastatin in treatment of hypercholesterolemia in non-insulin-dependent diabetes patients, a 6-month trial of once daily 10 mg-pravastatin was studied in 30 patients with fairly, well controlled non-insulin-dependent diabetes mellitus. For 27 patients who completed the study, serum total cholesterol and low-density lipoprotein cholesterol were significantly lower 16.7 +/- 2.3 and 20.2 +/- 3.3% from 286.7 +/- 5.9 and 198.6 +/- 7.2 mg/dl at before to 232.6 +/- 7.9 and 147.8 +/- 6.4 mg/dl at 4th week and 237.8 +/- 6.4 and 155.0 +/- 5.8 mg/dl at 24th week after treatment with pravastatin, respectively (P < 0.00001). Serum triglyceride level was decreased from 194.7 +/- 16.8 mg/dl to 175.0 +/- 16.8 mg/dl at 4th week and 176.6 +/- 14.1 mg/dl at 24th week and serum high-density lipoprotein cholesterol level was slightly increased from 45.4 +/- 2.8 mg/dl to 48.2 +/- 2.5 mg/dl at 4th week and 47.5 +/- 2.6 mg/dl at 24th week of pravastatin treatment, respectively (P > 0.05). There was no serious adverse effect except acute hepatitis in one patient who recovered spontaneously after drug withdrawal. Once daily 10 mg-pravastatin in effective in the treatment of hypercholesterolemia in patients with non-insulin-dependent diabetes mellitus.
S Soonthornpun; C Rattarasarn; R Leelawattana; A Thamprasit
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  80     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
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MeSH Terms
Anticholesteremic Agents / therapeutic use*
Diabetes Mellitus, Type 2 / complications*
Hypercholesterolemia / complications,  drug therapy*
Middle Aged
Pravastatin / therapeutic use*
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anticholesteremic Agents; 81093-37-0/Pravastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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