Document Detail

Effect of pravastatin on fatty acid profile of low density lipoprotein in patients with hypercholesterolemia.
MedLine Citation:
PMID:  8446653     Owner:  NLM     Status:  MEDLINE    
We gave pravastatin, an HMG-CoA reductase inhibitor, to 21 hypercholesterolemic patients for 12 weeks after they had been on dietary therapy for 12 weeks. In addition to inducing a significant reduction of total cholesterol and LDL-cholesterol, pravastatin significantly decreased the proportion of linoleic acid (18:2) and increased that of saturated (FA) (16:0 and 18:0) in the cholesterol ester of LDL. Linoleic acid was also reduced in the triglyceride of LDL. Besides, monounsaturated FA (16:1 and 18:1) were increased in the cholesterol ester, triglyceride and phospholipid of LDL, but the changes in monounsaturated FA were not statistically significant. The effect of pravastatin on the FA profile of LDL was similar to that of fibric acid derivatives. The mechanism as well as the clinical implication of these changes await further investigation.
C Y Hong; S J Lin; M S Chang; B N Chiang; P M Shen; M S Shiao
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  48     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC.
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MeSH Terms
Cholesterol / blood
Cholesterol, LDL / blood
Fatty Acids / blood*,  chemistry
Hypercholesterolemia / blood,  drug therapy*
Linoleic Acid
Linoleic Acids / blood
Lipoproteins, LDL / blood*,  chemistry
Middle Aged
Pravastatin / pharmacology*
Reg. No./Substance:
0/Cholesterol, LDL; 0/Fatty Acids; 0/Linoleic Acids; 0/Lipoproteins, LDL; 2197-37-7/Linoleic Acid; 57-88-5/Cholesterol; 81093-37-0/Pravastatin

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