| Effect of pravastatin on fatty acid profile of low density lipoprotein in patients with hypercholesterolemia. | |
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MedLine Citation:
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PMID: 8446653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We gave pravastatin, an HMG-CoA reductase inhibitor, to 21 hypercholesterolemic patients for 12 weeks after they had been on dietary therapy for 12 weeks. In addition to inducing a significant reduction of total cholesterol and LDL-cholesterol, pravastatin significantly decreased the proportion of linoleic acid (18:2) and increased that of saturated (FA) (16:0 and 18:0) in the cholesterol ester of LDL. Linoleic acid was also reduced in the triglyceride of LDL. Besides, monounsaturated FA (16:1 and 18:1) were increased in the cholesterol ester, triglyceride and phospholipid of LDL, but the changes in monounsaturated FA were not statistically significant. The effect of pravastatin on the FA profile of LDL was similar to that of fibric acid derivatives. The mechanism as well as the clinical implication of these changes await further investigation. |
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Authors:
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C Y Hong; S J Lin; M S Chang; B N Chiang; P M Shen; M S Shiao |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 48 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-04-08 Completed Date: 1993-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 155-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol / blood Cholesterol, LDL / blood Fatty Acids / blood*, chemistry Female Humans Hypercholesterolemia / blood, drug therapy* Linoleic Acid Linoleic Acids / blood Lipoproteins, LDL / blood*, chemistry Male Middle Aged Pravastatin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Fatty Acids; 0/Linoleic Acids; 0/Lipoproteins, LDL; 2197-37-7/Linoleic Acid; 57-88-5/Cholesterol; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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