Document Detail


Effect of posture on creatinine clearance in late pregnancy and after pregnancy.
MedLine Citation:
PMID:  18686345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To assess creatinine clearance that indicates glomerular filtration rate (GFR) and to demonstrate the effect of posture on creatinine clearance in late pregnancy compared to the non-pregnant state. METHODS: Twenty-six healthy pregnant women aged 19-30 years were studied for two sessions, first in their third trimester of pregnancy and then in a non-pregnant state at 6-12 weeks after delivery. In both sessions, creatinine clearance was assessed at three periods: the 24-h baseline, and at the end of 2-h sitting and 2-h lying (in left lateral decubitus position) periods. Urine and blood samples were collected for creatinine clearance measurement. RESULTS: The results showed that the 24-h creatinine clearance in late pregnancy was 28.3% higher than that in the non-pregnant state (122.6 +/- 26.2 vs 95.3 +/- 15.1 mL/min per 1.73 m2, P < 0.001). In late pregnancy, after 2-h sitting, creatinine clearance decreased significantly (10%) compared to the 24-h baseline (122.6 +/- 26.2 vs 110.4 +/- 28.6 mL/min per 1.73 m2, P < 0.001). Creatinine clearance rose back to the high baseline level after the pregnant woman laid in left lateral decubitus for 2 h. The decrease in creatinine clearance during prolonged sitting was not seen in the non-pregnant state. At any posture, the creatinine clearance was always higher in the pregnant state than in the non-pregnant. CONCLUSIONS: This study showed that creatinine clearance in late pregnancy was much higher than in the non-pregnant state, and was affected by sitting for up to 2 h. It might be wise for women to lay down in the left lateral decubitus position for a while after many hours of sitting when pregnancy is approaching its term.
Authors:
Supatra Lohsiriwat; Nathi Imrittha
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-09-04     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sislr@mahidol.ac.th
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MeSH Terms
Descriptor/Qualifier:
Adult
Creatinine / blood,  pharmacokinetics*,  urine
Female
Gestational Age*
Glomerular Filtration Rate
Humans
Metabolic Clearance Rate
Postpartum Period / metabolism*
Posture / physiology*
Pregnancy
Pregnancy Trimester, Third
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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