| Effect of posture on creatinine clearance in late pregnancy and after pregnancy. | |
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MedLine Citation:
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PMID: 18686345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess creatinine clearance that indicates glomerular filtration rate (GFR) and to demonstrate the effect of posture on creatinine clearance in late pregnancy compared to the non-pregnant state. METHODS: Twenty-six healthy pregnant women aged 19-30 years were studied for two sessions, first in their third trimester of pregnancy and then in a non-pregnant state at 6-12 weeks after delivery. In both sessions, creatinine clearance was assessed at three periods: the 24-h baseline, and at the end of 2-h sitting and 2-h lying (in left lateral decubitus position) periods. Urine and blood samples were collected for creatinine clearance measurement. RESULTS: The results showed that the 24-h creatinine clearance in late pregnancy was 28.3% higher than that in the non-pregnant state (122.6 +/- 26.2 vs 95.3 +/- 15.1 mL/min per 1.73 m2, P < 0.001). In late pregnancy, after 2-h sitting, creatinine clearance decreased significantly (10%) compared to the 24-h baseline (122.6 +/- 26.2 vs 110.4 +/- 28.6 mL/min per 1.73 m2, P < 0.001). Creatinine clearance rose back to the high baseline level after the pregnant woman laid in left lateral decubitus for 2 h. The decrease in creatinine clearance during prolonged sitting was not seen in the non-pregnant state. At any posture, the creatinine clearance was always higher in the pregnant state than in the non-pregnant. CONCLUSIONS: This study showed that creatinine clearance in late pregnancy was much higher than in the non-pregnant state, and was affected by sitting for up to 2 h. It might be wise for women to lay down in the left lateral decubitus position for a while after many hours of sitting when pregnancy is approaching its term. |
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Authors:
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Supatra Lohsiriwat; Nathi Imrittha |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 34 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-09-04 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Japan |
Other Details:
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Languages: eng Pagination: 337-42 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sislr@mahidol.ac.th |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Creatinine / blood, pharmacokinetics*, urine Female Gestational Age* Glomerular Filtration Rate Humans Metabolic Clearance Rate Postpartum Period / metabolism* Posture / physiology* Pregnancy Pregnancy Trimester, Third |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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