| Effect of posture on bronchial reactivity to inhaled methacholine in patients with mitral valve stenosis. | |
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MedLine Citation:
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PMID: 7956389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the effects of posture on bronchial reactivity in 12 patients with mitral valve stenosis (MS) and 10 with bronchial asthma (BA), a methacholine inhalation test was performed 2 h after being in either a supine or sitting position. All patients showed bronchial hyperreactivity to inhaled methacholine before the study. In MS patients, logarithmic values of the cumulative dose producing a 35 percent decrease in respiratory conductance (log PD35Grs) were significantly lower 2 h after being in a supine position than in those after being in a sitting position (0.71 +/- 0.78, 1.02 +/- 0.53 log units, respectively, p < 0.05). In BA patients, however, log PD35Grs did not show significant changes (0.42 +/- 0.51, 0.58 +/- 0.48 log units, respectively). Variables of pulmonary function tests showed no significant differences between the two positions in both patients with MS and BA. We conclude that the bronchial hyperreactivity in MS is enhanced after the supine position for 2 h and that the supine posture may play an important role in the pathogenesis of cardiac asthma. |
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Authors:
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Y Nishimura; H Maeda; A Hashimoto; K Tanaka; M Yokoyama |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Chest Volume: 106 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-09 Completed Date: 1994-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1391-5 Citation Subset: AIM; IM; S |
Affiliation:
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First Department of Internal Medicine, Kobe University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / complications, physiopathology Bronchial Hyperreactivity / complications, physiopathology* Bronchial Provocation Tests / methods, statistics & numerical data Dyspnea, Paroxysmal / etiology Female Humans Male Methacholine Chloride / diagnostic use* Middle Aged Mitral Valve Stenosis / complications, physiopathology* Respiratory Function Tests / statistics & numerical data Supine Position / physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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