Document Detail

Effect of posture on bronchial reactivity to inhaled methacholine in patients with mitral valve stenosis.
MedLine Citation:
PMID:  7956389     Owner:  NLM     Status:  MEDLINE    
To compare the effects of posture on bronchial reactivity in 12 patients with mitral valve stenosis (MS) and 10 with bronchial asthma (BA), a methacholine inhalation test was performed 2 h after being in either a supine or sitting position. All patients showed bronchial hyperreactivity to inhaled methacholine before the study. In MS patients, logarithmic values of the cumulative dose producing a 35 percent decrease in respiratory conductance (log PD35Grs) were significantly lower 2 h after being in a supine position than in those after being in a sitting position (0.71 +/- 0.78, 1.02 +/- 0.53 log units, respectively, p < 0.05). In BA patients, however, log PD35Grs did not show significant changes (0.42 +/- 0.51, 0.58 +/- 0.48 log units, respectively). Variables of pulmonary function tests showed no significant differences between the two positions in both patients with MS and BA. We conclude that the bronchial hyperreactivity in MS is enhanced after the supine position for 2 h and that the supine posture may play an important role in the pathogenesis of cardiac asthma.
Y Nishimura; H Maeda; A Hashimoto; K Tanaka; M Yokoyama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  106     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-09     Completed Date:  1994-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1391-5     Citation Subset:  AIM; IM; S    
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Asthma / complications,  physiopathology
Bronchial Hyperreactivity / complications,  physiopathology*
Bronchial Provocation Tests / methods,  statistics & numerical data
Dyspnea, Paroxysmal / etiology
Methacholine Chloride / diagnostic use*
Middle Aged
Mitral Valve Stenosis / complications,  physiopathology*
Respiratory Function Tests / statistics & numerical data
Supine Position / physiology*
Time Factors
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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