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Effect of postpartum anxiety on the colostral milk beta-endorphin concentrations of breastfeeding mothers.
MedLine Citation:
PMID:  12521879     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Peripartal maternal apprehension and anxiety are associated with abnormal labour, dystocia and higher rates of fetal and maternal morbidity. Since colostral beta-endorphin (beta-EP) concentrations are twofold higher than circulating levels, we hypothesised that substantial maternal emotional distress in puerperium might induce consistent changes in colostral beta endorphin galactopoiesis. To test this hypothesis, we assessed the effects of postpartum maternal anxiety (State-Trait Anxiety Inventory-Y form, Spielberger CD, Palo Alto, CA, USA, 1983) on colostral milk beta-EP levels (beta-endorphin 125I RIA, INCSTAR Corporation-Stillwater, Minnesota, USA) in a population of healthy lactating mothers, on the fourth postpartum discharge day, 14 after at term vaginal delivery, 14 after premature (> or = 34 <37 gestational weeks) vaginal delivery, and 14 after elective cesarean section. The colostral milk beta-EP concentrations of mothers who vaginally delivered at term or prematurely were significantly higher on the fourth postpartum day (6.0+/-0.5 and 6.6+/-0.7 vs. 4.3+/-0.4 pmol/l, respectively; P <0.05) than colostral levels of mothers who underwent caesarean section. At the same time, while trait anxiety levels (T, age corrected values) were unaffected by route and mode of delivery, in mothers presenting increased colostral milk beta-EP galactopoiesis after vaginal delivery there was a statistically significant negative correlation (r-0.40; P <0.03) between colostral milk beta-EP concentrations and trait anxiety levels. These data indicate that the labour pain and the vaginal delivery process play a central role in increasing colostral opioid availability for the breastfed neonate; peripartal maternal anxiety is a negative psychobiological determinant in opioid galactopoiesis, and possibly in the postnatal development of several related biological functions of growing infants.
Authors:
V Zanardo; S Nicolussi; F Favaro; D Faggian; M Plebani; F Marzari; F Freato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  21     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  130-4     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Padua University School of Medicine, Padova, Italy. vincenzo.zanardo@libero.it
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