Document Detail

Effect of postoperative extradural morphine on ADH secretion.
MedLine Citation:
PMID:  3986069     Owner:  NLM     Status:  MEDLINE    
The effect of extradural morphine on antidiuretic hormone (ADH) secretion was assessed for the first 6 h after surgery in three groups of patients. Surgery was conducted under extradural bupivacaine: thereafter patients in group I (n = 6) received further injections of bupivacaine, patients in group II (n = 6) received an extradural injection of morphine and in patients in group III (n = 5) both bupivacaine and morphine, were administered extradurally. In group I, plasma ADH values remained unchanged throughout the study. In contrast, in the two groups of patients receiving extradural morphine a delayed and stepwise increase in plasma ADH concentration was documented. These results indicate that extradural morphine induces ADH secretion and suggest that this effect is the consequence of the migration of morphine to the brainstem.
A M Korinek; M Languille; F Bonnet; M Thibonnier; P Sasano; A Lienhart; P Viars
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  57     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-07     Completed Date:  1985-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  407-11     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Epidural
Epidural Space
Morphine / administration & dosage,  therapeutic use*
Pain, Postoperative / drug therapy,  metabolism*
Time Factors
Vasopressins / blood,  secretion*
Reg. No./Substance:
11000-17-2/Vasopressins; 2180-92-9/Bupivacaine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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