Document Detail

Effect of positive-end expiratory pressure on accuracy of thermal-dye measurements of lung water.
MedLine Citation:
PMID:  3884898     Owner:  NLM     Status:  MEDLINE    
The thermal-dye indicator dilution technique of measuring extravascular lung water (EVLW-TD) correlates well with gravimetric measurement of lung water (EVLW-GR) when no positive-end expiratory pressure (PEEP) is used in both normal and edematous lungs. PEEP is often used to raise arterial oxygen tension in acute respiratory failure. This study was designed to answer the question: Does PEEP have an effect on the accuracy of the EVLW measurement by thermal dye? Sixteen mongrel dogs were anesthetized and intubated. Arterial and PA catheters were placed. They were divided into three groups and ventilated at PEEP levels of 5, 10, or 15 cm H2O. Fluids were given to minimize decrease in cardiac output with institution of PEEP. They were maintained for 5 hr with measurement of vital signs made hourly and measurement of blood gases and EVLW-TD made at baseline, 1, 3, and 5 hr. After final measurements, gravimetric determination of EVLW was done. Correlation between EVLWTD and EVLWGR remained good when low levels of PEEP were used. At 5 cm H2O PEEP, EVLWTD was 7.5 +/- 0.9 and EVLWGR was 5.4 +/- .3. At 10 cm H2O PEEP, they were 10.0 +/- 0.9 and 6.5 +/- 0.3. The correlations were 0.87 and 0.97, respectively. However, at 15 cm H2O PEEP, EVLWTD was 11.4 +/- 1.3 and EVLWGR was 7.5 +/- 0.6, with a correlation of only 0.59. The correlation between the two techniques seems to break down with higher levels of PEEP in dogs with normal lungs.
B L Enderson; C Rice; G S Moss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  38     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-29     Completed Date:  1985-04-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-30     Citation Subset:  IM    
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MeSH Terms
Cardiac Output
Dye Dilution Technique
Positive-Pressure Respiration*
Pulmonary Edema / diagnosis*,  physiopathology,  therapy
Pulmonary Wedge Pressure
Thermodilution / methods

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