| Effect of positive end-expiratory pressure on regional ventilation distribution during bronchoconstriction in rabbit studied by synchrotron radiation imaging. | |
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MedLine Citation:
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PMID: 21494104 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: To assess the effects of positive end-expiratory pressure on regional ventilation distribution in normal lung and after histamine-induced bronchoconstriction. DESIGN:: Experimental study. SETTING:: International research laboratory. SUBJECTS:: Six healthy New Zealand rabbits weighing 2.5 ± 0.1 kg. INTERVENTIONS:: Rabbits were anesthetized, tracheostomized, paralyzed, and mechanically ventilated. Synchrotron radiation computed tomography images of tissue density and specific ventilation were acquired using K-edge subtraction imaging with inhaled stable xenon gas in middle and caudal thoracic levels on 0 and 5 cm H2O positive end-expiratory pressure at baseline and twice after histamine inhalation. MEASUREMENTS AND MAIN RESULTS:: At baseline, a positive end-expiratory pressure of 5 cm H2O significantly increased lung volume. Histamine inhalation caused patchy areas of decreased specific ventilation, including some areas with no ventilation. After histamine, positive end-expiratory pressure significantly increased the area of well-ventilated lung regions and decreased the heterogeneity of specific ventilation. This improvement went together with a significant but limited increase in the area of hyperinflated lung zones. CONCLUSIONS:: The findings of this study suggest that in mechanically ventilated rabbit with severely heterogeneous bronchoconstriction, a positive end-expiratory pressure of 5 cm H2O significantly improves regional ventilation homogeneity through dilation of flow-limited airways and recruitment of closed airways. |
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Authors:
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Liisa Porra; Heikki Suhonen; Pekka Suortti; Anssi R A Sovijärvi; Sam Bayat |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-24 |
Journal Detail:
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Title: Critical care medicine Volume: - ISSN: 1530-0293 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-4-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the European Synchrotron Radiation Facility (LP, HS), Grenoble, France; the Department of Physics (LP, PS), University of Helsinki, Helsinki, Finland; the Department of Clinical Physiology and Nuclear Medicine (ARAS), Helsinki University Central Hospital, Helsinki, Finland; and Université de Picardie Jules Vern (SB), EA4285 Péritox UMI01 INERIS and CHU Amiens, Amiens, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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