Document Detail

Effect of positive end-expiratory pressure on inflammatory response in oleic acid-induced lung injury and whole-lung lavage-induced lung injury.
MedLine Citation:
PMID:  17285413     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The present study investigated the effects of positive end-expiratory pressure (PEEP) on the inflammatory response in two different lung injury models: edematous lung induced by oleic acid (OA); and atelectatic lung induced by whole-lung lavage (LAV). METHODS: Japanese white rabbits (n = 28) were allocated to one of the two lung injury (OA or LAV) groups, and each group was treated with intermittent positive pressure ventilation, using zero end-expiratory pressure (ZEEP) or PEEP (1 cm H(2)O above the lower inflection point [LIP]). Thus, the animals were divided into LAV-ZEEP, LAV-PEEP, OA-ZEEP, and OA-PEEP groups. Blood and bronchoalveolar lavage fluid (BALF) were sampled 3 h after ventilatory treatment to analyze interleukin (IL)-8 levels. RESULTS: Pa(O) (2) was significantly decreased after the induction of lung injury, but was significantly higher in the PEEP groups compared to the ZEEP groups for each lung injury. Serum IL-8 levels were elevated in both experimental models. Serum IL-8 levels were significantly lower in LAV-PEEP than in LAV-ZEEP, whereas no difference was noted between OA-PEEP and OA-ZEEP. BALF IL-8 levels were lower in LAV-PEEP than in LAV-ZEEP. PEEP above LIP attenuated the elevation of IL-8 in BALF and serum in atelectatic lungs, but did not attenuate these increases in the edematous lungs. CONCLUSION: These results suggest that the protective effects of PEEP on injured lungs may depend on the underlying lung pathology.
Koichi Nakazawa; Kuninori Yokoyama; Naoko Yamakawa; Koshi Makita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-30
Journal Detail:
Title:  Journal of anesthesia     Volume:  21     ISSN:  0913-8668     ISO Abbreviation:  J Anesth     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-04-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Department of Anesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
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MeSH Terms
Analysis of Variance
Blood Gas Analysis / methods
Blood Pressure
Bronchoalveolar Lavage / adverse effects*,  methods
Bronchoalveolar Lavage Fluid / chemistry
Disease Models, Animal
Interleukin-8 / analysis,  blood
Oleic Acid*
Pneumonia / chemically induced,  pathology,  therapy*
Positive-Pressure Respiration / methods*
Proteins / metabolism
Pulmonary Atelectasis / etiology,  metabolism,  therapy*
Pulmonary Edema / chemically induced,  pathology,  therapy*
Respiration, Artificial / methods
Respiratory Distress Syndrome, Adult / prevention & control
Sodium Chloride / administration & dosage,  adverse effects
Time Factors
Reg. No./Substance:
0/Interleukin-8; 0/Proteins; 112-80-1/Oleic Acid; 7647-14-5/Sodium Chloride

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