Document Detail


Effect of porcine somatotropin on the response of growing pigs to acute challenges of glucose, insulin and epinephrine and during a hyperinsulinemic-euglycemic clamp.
MedLine Citation:
PMID:  8325009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Response of tissues to homeostatic signals may play a role in the mediation of nutrient partitioning effects of somatotropin. To investigate this, the effects of exogenous porcine somatotropin (pST) on the metabolic responses to a series of intravenous challenges with dextrose, insulin and epinephrine were examined in twelve crossbred barrows (65 kg). In addition, the hyperinsulinemic-euglycemic clamp technique was used to further explore effects of pST on insulin resistance in eight of these animals. Pigs received daily sc injections of either pituitary-derived pST (120 micrograms/kg bw) or an equivalent volume of excipient for 28 d. Treatment with pST resulted in a chronic elevation of plasma glucose, insulin and non-esterified fatty acid concentrations and lowered glucagon concentrations. Acute iv challenges of dextrose (100 mg/kg bw), insulin (1.0 micrograms/kg bw), and epinephrine (2.2 micrograms/kg bw) were administered on days 21, 22, and 23 of the treatment period, respectively. Hyperinsulinemic-euglycemic clamps were carried out on day 28. Effects of pST were most dramatic for responses associated with insulin. In pST-treated pigs, insulin response to dextrose infusion was enhanced, while glucose response to insulin was attenuated and glucose clearance rate was reduced. During the hyperinsulinemic-euglycemic clamp, dextrose infusion rate required to maintain euglycemia during physiologic elevations of insulin was reduced in pST-treated pigs to 28% of control. In pST-treated pigs, glucose response to epinephrine challenge was halved, while insulin response was increased three-fold. Therefore, one mechanism by which pST shifts the nutrient partition is by altering metabolic responses to homeostatic signals. In growing pigs, this is especially evident for glucose response to insulin.
Authors:
D Wray-Cahen; R D Boyd; D E Bauman; D A Ross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  10     ISSN:  0739-7240     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-08-09     Completed Date:  1993-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-15     Citation Subset:  IM    
Affiliation:
Department of Animal Science Cornell University, Ithaca, NY 14853.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Epinephrine / administration & dosage,  pharmacology*
Fatty Acids, Nonesterified / blood
Glucagon / blood
Glucose / administration & dosage,  pharmacology*
Glucose Clamp Technique / veterinary
Growth Hormone / administration & dosage,  pharmacology*
Homeostasis / drug effects
Infusions, Intravenous / veterinary
Injections, Subcutaneous / veterinary
Insulin / administration & dosage,  blood,  pharmacology*
Insulin Resistance
Male
Random Allocation
Swine / blood,  growth & development,  metabolism*
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 50-99-7/Glucose; 51-43-4/Epinephrine; 9002-72-6/Growth Hormone; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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