| Effect of polymyxin B-immobilized fiber hemoperfusion on respiratory impairment, hepatocellular dysfunction, and leucopenia in a neonatal sepsis model. | |
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MedLine Citation:
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PMID: 19802625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Sepsis and septic shock remain a major source of morbidity and mortality in neonates despite advances in antimicrobials and aggressive supportive care. Our aim was to study the effects of polymyxin-B direct hemoperfusion (PMX-DHP) therapy on sepsis-induced respiratory impairment, liver dysfunction and leucopenia in a neonatal cecal ligation and perforation (CLP) model. METHODS: Fourteen anesthetized and mechanically ventilated 3-day-old piglets underwent CLP and an arteriovenous extracorporeal circuit from 3 h until 6 h post-CLP, with a PMX column in the PMX-DHP treated group (7 piglets). Changes in oxygen saturation, PCO(2), base excess, white blood cell (WBC) count, platelet count, hematocrit (Hct%), serum glutamate pyruvate transaminase (SGPT), and serum glutamic oxaloacetic transaminase were measured before CLP and at 1, 3 and 6 h after. RESULTS: At 6 h, the PMX-DHP group showed lower Hct%, and SGPT in comparison to the control group, but higher oxygen saturation and WBC count. No effects on the platelet count were found. The survival times of the PMX-DHP group were longer than in control. CONCLUSION: PMX-DHP therapy limited the respiratory impairment, liver dysfunction and leucopenia in a neonatal septic model, which resulted in an improvement of survival time. |
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Authors:
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Mohamed Hamed Hussein; Ghada A Daoud; Hiroki Kakita; Shin Kato; Tatenobu Goto; Michi Kamei; Kenji Goto; Yasuhiko Ozaki; Tetsuya Ito; Sumio Fukuda; Ineko Kato; Satoshi Suzuki; Takashi Hashimoto; Hajime Togari |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-03 |
Journal Detail:
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Title: Pediatric surgery international Volume: 26 ISSN: 1437-9813 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
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Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
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Department of Pediatrics Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. drmhamed@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Anti-Bacterial Agents / pharmacology Coated Materials, Biocompatible* Disease Models, Animal Follow-Up Studies Hemoperfusion / methods* Hepatocytes / pathology Leukopenia / metabolism, therapy* Liver Diseases / metabolism, pathology, therapy* Oxygen Consumption Polymyxin B / pharmacology* Polystyrenes Respiratory Insufficiency / metabolism, therapy* Sepsis / metabolism, therapy* Swine Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Coated Materials, Biocompatible; 0/Polystyrenes; 1404-26-8/Polymyxin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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