Document Detail

Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability.
MedLine Citation:
PMID:  8539619     Owner:  NLM     Status:  MEDLINE    
Development is buffered against unpredictable environmental and genetic effects. Here, a molecular genetic analysis of one type of developmental homeostasis, the establishment of thoracic segmental identity under the control of the Ultrabithorax (Ubx) gene in Drosophila melanogaster, is presented. Flies were artificially selected for differential sensitivity to the induction of bithorax phenocopies by ether vapor. The experiments demonstrated that increased sensitivity to ether correlated with a loss of expression of UBX in the third thoracic imaginal discs and that a significant proportion of the genetic variation for transcriptional stability can be attributed to polymorphism in the Ubx gene.
G Gibson; D S Hogness
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  271     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  200-3     Citation Subset:  IM    
Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.
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MeSH Terms
Base Sequence
DNA-Binding Proteins / genetics*
Drosophila Proteins*
Drosophila melanogaster / drug effects,  genetics*
Ether, Ethyl / pharmacology
Genes, Homeobox*
Genes, Regulator*
Homeodomain Proteins / genetics*
Linkage Disequilibrium
Molecular Sequence Data
Nucleic Acid Heteroduplexes
Polymerase Chain Reaction
Polymorphism, Genetic*
Selection, Genetic
Transcription Factors*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Nucleic Acid Heteroduplexes; 0/Transcription Factors; 0/Ubx protein, Drosophila; 60-29-7/Ether, Ethyl
Comment In:
Science. 1996 Jan 12;271(5246):160-1   [PMID:  8539613 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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