| Effect of polydextrose on intestinal microbes and immune functions in pigs. | |
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MedLine Citation:
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PMID: 17391567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary fibre has been proposed to decrease risk for colon cancer by altering the composition of intestinal microbes or their activity. In the present study, the changes in intestinal microbiota and its activity, and immunological characteristics, such as cyclo-oxygenase (COX)-2 gene expression in mucosa, in pigs fed with a high-energy-density diet, with and without supplementation of a soluble fibre (polydextrose; PDX) (30 g/d) were assessed in different intestinal compartments. PDX was gradually fermented throughout the intestine, and was still present in the distal colon. Irrespective of the diet throughout the intestine, of the four microbial groups determined by fluorescent in situ hybridisation, lactobacilli were found to be dominating, followed by clostridia and Bacteroides. Bifidobacteria represented a minority of the total intestinal microbiota. The numbers of bacteria increased approximately ten-fold from the distal small intestine to the distal colon. Concomitantly, also concentrations of SCFA and biogenic amines increased in the large intestine. In contrast, concentrations of luminal IgA decreased distally but the expression of mucosal COX-2 had a tendency to increase in the mucosa towards the distal colon. Addition of PDX to the diet significantly changed the fermentation endproducts, especially in the distal colon, whereas effects on bacterial composition were rather minor. There was a reduction in concentrations of SCFA and tryptamine, and an increase in concentrations of spermidine in the colon upon PDX supplementation. Furthermore, PDX tended to decrease the expression of mucosal COX-2, therefore possibly reducing the risk of developing colon cancer-promoting conditions in the distal intestine. |
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Authors:
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Francesca Fava; Harri Mäkivuokko; Hilkka Siljander-Rasi; Heli Putaala; Kirsti Tiihonen; Julian Stowell; Kieran Tuohy; Glenn Gibson; Nina Rautonen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-29 |
Journal Detail:
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Title: The British journal of nutrition Volume: 98 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-18 Completed Date: 2007-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 123-33 Citation Subset: IM |
Affiliation:
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Food Microbial Sciences Unit, School of Food Biosciences, University of Reading, Reading, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis Cecum / immunology, microbiology Colon / immunology, microbiology Cyclooxygenase 1 / genetics Cyclooxygenase 2 / genetics Dietary Fiber / administration & dosage*, analysis Dietary Supplements Energy Intake / immunology Fatty Acids, Volatile / analysis Female Food Additives / administration & dosage*, analysis Gene Expression / genetics Glucans / administration & dosage*, analysis Immunoglobulin A / analysis Intestinal Mucosa / immunology Intestine, Small / immunology, microbiology Intestines / immunology, microbiology* Male Swine |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fatty Acids, Volatile; 0/Food Additives; 0/Glucans; 0/Immunoglobulin A; 68424-04-4/polydextrose; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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