Document Detail

Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization-embryo transfer (IVF-ET) programs.
MedLine Citation:
PMID:  19200984     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To establish the effect of chlorinated organic compounds on fertility. DESIGN: We analyzed the influence of polychlorinated biphenyls (PCBs) and pesticides in follicular fluid on the number of fertilized oocytes, the quality of oocytes and embryos, pregnancy rate, and number of embryos cryoconserved in IVF-ET program. SETTING: Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic. PATIENT(S): Patients from the Center of Assisted Reproduction. INTERVENTION(S): We collected the follicular fluid of 99 infertile women. MAIN OUTCOME MEASURE(S): The levels of xenobiotics in follicular fluid were examined by high-resolution mass spectrometry and gas chromatography. Correlations between the levels of xenobiotics and IVF-ET program results were statistically analyzed. RESULT(S): The PCB levels varied from 0.1 to 254.6 ng/g of fat. Levels of DDT and its metabolites varied from 0.3 to 35 228.8 ng/g of fat. A correlation was found between the number of diploid oocytes and the level of DDT, the fertilization of oocytes and level of PCB 158, and the pregnancy rate and the number of embryos cryoconserved and levels of PCB 47. CONCLUSION(S): Xenobiotics can be detected in the fat compartment of the follicular fluid. Some correlation to the IVF-ET program results was established, to a degree that might be considered of concern, although it was not statistically significant at the 5% level.
Simona Jirsov?; Jarom?r Masata; Libor Jech; Jana Zv?rov?
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-06
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1831-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic.
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MeSH Terms
DDT / pharmacology*
Embryo Transfer* / methods
Environmental Pollutants / pharmacology
Fertilization in Vitro* / methods
Follicular Fluid / drug effects*,  physiology
Infertility, Female / chemically induced,  diagnosis,  therapy
Pesticides / pharmacology
Polychlorinated Biphenyls / pharmacology*
Pregnancy Rate
Treatment Outcome
Xenobiotics / pharmacology
Reg. No./Substance:
0/Environmental Pollutants; 0/Pesticides; 0/Polychlorinated Biphenyls; 0/Xenobiotics; 50-29-3/DDT

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