| Effect of polybasic acids on structure of aluminum hydroxycarbonate gel. | |
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MedLine Citation:
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PMID: 7205579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of oxalic acid, citric acid, and their sodium salts on the structure of aluminum hydroxycarbonate gel was studied to illustrate the various mechanisms by which polybasic acids interact with aluminum hydroxycarbonate gel. Analysis of changes in the pH-stat titrigram, the carbonate to aluminum ratio, the aluminum content of the supernate following centrifugation, and the adsorption of the organic solute indicates that polybasic acids may: (a) partially neutralize the aluminum hydroxycarbonate gel by a general acid effect, (b) modify the aluminum hydroxycarbonate surface by adsorption of the anionic form of the polybasic acid, (c) extract aluminum by the formation of a soluble complex, and (d) lead to the precipitation of a new crystalline phase. |
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Authors:
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M K Wang; J L White; S L Hem |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 69 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1981-05-26 Completed Date: 1981-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 668-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum Hydroxide* Chemistry, Pharmaceutical Citrates* Drug Stability Oxalates* |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Oxalates; 12538-82-8/basic aluminum carbonate gel; 21645-51-2/Aluminum Hydroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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