Document Detail


Effect of polybasic acids on structure of aluminum hydroxycarbonate gel.
MedLine Citation:
PMID:  7205579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of oxalic acid, citric acid, and their sodium salts on the structure of aluminum hydroxycarbonate gel was studied to illustrate the various mechanisms by which polybasic acids interact with aluminum hydroxycarbonate gel. Analysis of changes in the pH-stat titrigram, the carbonate to aluminum ratio, the aluminum content of the supernate following centrifugation, and the adsorption of the organic solute indicates that polybasic acids may: (a) partially neutralize the aluminum hydroxycarbonate gel by a general acid effect, (b) modify the aluminum hydroxycarbonate surface by adsorption of the anionic form of the polybasic acid, (c) extract aluminum by the formation of a soluble complex, and (d) lead to the precipitation of a new crystalline phase.
Authors:
M K Wang; J L White; S L Hem
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  69     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  668-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aluminum Hydroxide*
Chemistry, Pharmaceutical
Citrates*
Drug Stability
Oxalates*
Chemical
Reg. No./Substance:
0/Citrates; 0/Oxalates; 12538-82-8/basic aluminum carbonate gel; 21645-51-2/Aluminum Hydroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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