Document Detail

Effect of polyaspartic acid on CdCl2-induced nephrotoxicity in the rat.
MedLine Citation:
PMID:  7688538     Owner:  NLM     Status:  MEDLINE    
We produced an animal model of CdCl2 nephrotoxicity in rats, and treated them with polyaspartic acid (PAA) to prevent renal damage. Male Sprague-Dawley (SD) rats (190-200 g) were used to induce proximal renal tubular damage by daily injection of CdCl2 3.0 mg/1,000 g body wt for 2 wk. CdCl2-exposed SD rats exhibited significant increases in urine volume, urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and fractional excretion of sodium (FENa) and a decrease in the percentage of tubular reabsorption of phosphate (%TRP). Of these indicators of proximal tubular function, AAP and %TRP are more sensitive than NAG or FENa. No glycosuria or aminoaciduria, however, were observed. PAA markedly improved these indicators of proximal tubular function. Daily urinary protein excretion and creatinine clearance, on the other hand, did not change after administration of PAA. Cd concentrations in the cortex were 3 times higher than in the medulla, however, there were no differences between Cd-treated rats and PAA-treated rats. Our animal model is an excellent one for determining the effect of cadmium on renal proximal tubule damage. PAA appears to be useful in the treatment of CdCl2 nephrotoxicity.
T Shibasaki; H Nakano; I Ohno; F Ishimoto; O Sakai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  37     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:    1993 May-Jun
Date Detail:
Created Date:  1993-09-14     Completed Date:  1993-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Acetylglucosaminidase / urine
Aminopeptidases / urine
Antigens, CD13
Cadmium / toxicity*
Cadmium Chloride
Chlorides / toxicity*
Disease Models, Animal
Kidney Tubules, Proximal / drug effects*,  metabolism
Peptides / administration & dosage,  pharmacology*
Phosphates / metabolism
Rats, Sprague-Dawley
Sodium / urine
Reg. No./Substance:
0/Chlorides; 0/Peptides; 0/Phosphates; 10108-64-2/Cadmium Chloride; 26063-13-8/polyaspartate; 7440-23-5/Sodium; 7440-43-9/Cadmium; EC; EC 3.4.11.-/Aminopeptidases; EC, CD13

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