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Effect of platelet-rich plasma on the healing of mandibular defects treated with bone allograft. A radiographic study in dogs.
MedLine Citation:
PMID:  23013307     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: The purpose of this study was to radiographically analyze the effect of autologous PRP on the healing of fresh frozen bone allograft (FFBA) placed in surgically created resection defects in mandibles of dogs. Materials and methods: Bilateral resection defects measuring 1.5 cm x 1 cm were surgically created on the inferior border of the mandible in ten adult male dogs. The defects were randomly divided into three groups: C, FFBA and FFBA/PRP. In Group C, the defect was filled by blood clot only. In Group FFBA, the defect was filled with particulate fresh frozen bone allograft. In Group FFBA/PRP, it was filled with particulate fresh frozen bone allograft combined with PRP. At 90 days post-operative, standardized radiographs of the mandibles were obtained and results were quantitatively evaluated.Results: Analysis of digitized radiographs indicated that non-PRP grafts were significantly less dense than the PRP grafts. Group FFBA/PRP also presented a statistically greater mineralized tissue area than Groups C and FFBA. Conclusion: Within the limits of this study, it can be concluded that PRP enhanced the healing of FFBA in resection defects in mandibles of dogs.
Authors:
Michel Reis Messora; Maria J H Nagata; Stephen E Fucini; Natália M Pola; Natália Campos; Guillermo C V Oliveira; Alvaro F Bosco; Valdir G Garcia; Flávia A C Furlaneto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-26
Journal Detail:
Title:  The Journal of oral implantology     Volume:  -     ISSN:  0160-6972     ISO Abbreviation:  J Oral Implantol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801086     Medline TA:  J Oral Implantol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a School of Dentistry of Ribeirão Preto, USP - University of São Paulo, Division of Periodontics, Department of Surgery and Bucco-Maxillofacial Traumato, School of Dentistry of Ribeirão Preto, USP - University of São Paulo.
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