| Effect of platelet activating factor on reticuloendothelial system function. | |
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MedLine Citation:
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PMID: 1892549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of platelet activating factor (PAF) injections on the uptake of 99mTc-SC (99mTc-SC (99mTc-sulphur colloid) was determined in vivo. PAF (2 micrograms) injected intravenously into unanaesthetized, unrestrained rats was associated with the development of lesions in the small intestine and alteration of 99mTc-SC uptake in vivo. 99mTc-SC uptake into the lung was increased while spleen uptake was decreased. Pretreatment of the animals with a PAF antagonist, SRI-64-441, prevented the intestinal lesions and alterations of 99mTc-SC uptake. Macrophages, isolated from lung lavage of the PAF-treated rats, demonstrated a decreased generation of hydrogen peroxide in vitro. The present results suggest that, in addition to its other effects on the immune system, PAF can also alter the in vivo phagocytic activity of the reticuloendothelial system in the rat. |
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Authors:
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M Trop; E J Schiffrin; E A Carter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 17 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 193-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Massachusetts General Hospital, Boston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Burns / immunology, pathology, physiopathology Cecum / immunology, pathology Disease Models, Animal Injections, Intravenous Intestine, Small / immunology, pathology Mononuclear Phagocyte System / physiology* Necrosis Platelet Activating Factor / pharmacology* Rats Stomach / immunology, pathology Technetium Tc 99m Sulfur Colloid |
| Grant Support | |
ID/Acronym/Agency:
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DK 34854/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Platelet Activating Factor; 0/Technetium Tc 99m Sulfur Colloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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