Document Detail


Effect of a platelet-activating factor antagonist, E5880, on cerebrovasospasm following subarachnoid hemorrhage in a canine double-hemorrhage model.
MedLine Citation:
PMID:  12445578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of a platelet-activating factor (PAF) antagonist, E5880 (1-ethyl-2-[N-(2-methoxy)benzoyl-N-[(2)-2-methoxy-3-(4-octadecycarbamoylox)piperidinocarbonyloxy-propyloxy]carbonyl]aminomethyl-pyridiniumchloride), on subarachnoid hemorrhage-induced prolongation of cerebral circulation time and decrease in the basilar artery diameter in a canine double-hemorrhage model. Animals were assigned to three groups, control (saline), E5880 1.2 mg/kg and E5880 2.4 mg/kg. For measurement of cerebral circulation time, regions of interest were chosen at the basilar artery and the straight sinus in order to obtain time-density curves. Cerebral circulation time was defined as the difference between the arterial and venous peaks. Cerebral circulation time and basilar artery diameter were assessed by intra-arterial digital subtraction angiography (IA-DSA) on Days 0, 2 and 7. The prolongation of cerebral circulation time following subarachnoid hemorrhage was significantly inhibited by intravenous administration of 2.4 mg/kg of E5880. Basilar artery constriction was also reduced by E5880. Thus, E5880 had preventive effects on the prolongation of cerebral circulation time and the vasoconstriction of basilar artery in this model. These results suggest that E5880 may have a preventive effect on neurological symptoms aggravated by cerebrovascular lesions following subarachnoid hemorrhage.
Authors:
Yoshihisa Abe; Hidetoshi Kasuya; Suguru Suzuki; Yoshiharu Yamanishi; Tomokatsu Hori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  455     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-05-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science B.V.
Affiliation:
Developmental Pharmacology Research Section, Drug Safety and Disposition Research Laboratories, Eisai Company, Limited, Tsukuba City, Ibaraki, 300-2635, Japan. y2-abe@hhc.eisai.co.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Basilar Artery / drug effects,  physiopathology
Cerebrovascular Circulation / drug effects
Disease Models, Animal
Dogs
Female
Male
Piperidines / pharmacology*
Platelet Activating Factor / antagonists & inhibitors*
Pyridinium Compounds / pharmacology*
Subarachnoid Hemorrhage / complications*
Time Factors
Vasoconstriction / drug effects
Vasospasm, Intracranial / etiology,  physiopathology,  prevention & control*
Chemical
Reg. No./Substance:
0/Piperidines; 0/Platelet Activating Factor; 0/Pyridinium Compounds; 128420-61-1/E 5880

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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