| Effect of a platelet-activating factor antagonist, E5880, on cerebrovasospasm following subarachnoid hemorrhage in a canine double-hemorrhage model. | |
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MedLine Citation:
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PMID: 12445578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of a platelet-activating factor (PAF) antagonist, E5880 (1-ethyl-2-[N-(2-methoxy)benzoyl-N-[(2)-2-methoxy-3-(4-octadecycarbamoylox)piperidinocarbonyloxy-propyloxy]carbonyl]aminomethyl-pyridiniumchloride), on subarachnoid hemorrhage-induced prolongation of cerebral circulation time and decrease in the basilar artery diameter in a canine double-hemorrhage model. Animals were assigned to three groups, control (saline), E5880 1.2 mg/kg and E5880 2.4 mg/kg. For measurement of cerebral circulation time, regions of interest were chosen at the basilar artery and the straight sinus in order to obtain time-density curves. Cerebral circulation time was defined as the difference between the arterial and venous peaks. Cerebral circulation time and basilar artery diameter were assessed by intra-arterial digital subtraction angiography (IA-DSA) on Days 0, 2 and 7. The prolongation of cerebral circulation time following subarachnoid hemorrhage was significantly inhibited by intravenous administration of 2.4 mg/kg of E5880. Basilar artery constriction was also reduced by E5880. Thus, E5880 had preventive effects on the prolongation of cerebral circulation time and the vasoconstriction of basilar artery in this model. These results suggest that E5880 may have a preventive effect on neurological symptoms aggravated by cerebrovascular lesions following subarachnoid hemorrhage. |
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Authors:
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Yoshihisa Abe; Hidetoshi Kasuya; Suguru Suzuki; Yoshiharu Yamanishi; Tomokatsu Hori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 455 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-05-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 127-33 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science B.V. |
Affiliation:
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Developmental Pharmacology Research Section, Drug Safety and Disposition Research Laboratories, Eisai Company, Limited, Tsukuba City, Ibaraki, 300-2635, Japan. y2-abe@hhc.eisai.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basilar Artery / drug effects, physiopathology Cerebrovascular Circulation / drug effects Disease Models, Animal Dogs Female Male Piperidines / pharmacology* Platelet Activating Factor / antagonists & inhibitors* Pyridinium Compounds / pharmacology* Subarachnoid Hemorrhage / complications* Time Factors Vasoconstriction / drug effects Vasospasm, Intracranial / etiology, physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 0/Platelet Activating Factor; 0/Pyridinium Compounds; 128420-61-1/E 5880 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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