Document Detail


Effect of placebo on ambulatory blood pressure monitoring in children.
MedLine Citation:
PMID:  22623022     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ambulatory blood pressure monitoring (ABPM) has been proposed as a useful tool for more accurately diagnosing hypertension (HTN) and evaluating blood pressure (BP) response in pediatric anti-hypertensive trials. ABPM captures multiple BP measurements during routine daily activities and is thus an excellent method for identifying white-coat HTN. Additionally, ABPM measurements in adults do not demonstrate the placebo effect commonly seen with casual BP measurements, although this has yet to be evaluated in children. Therefore,, the aim of this study was to assess the effect of placebo on ABPM measurements in children.
METHODS: A total of 141 children aged 5-16 years with elevated BP were randomized into a multi-center, single-blind, cross-over trial. Subjects received a placebo pill prior to wearing a 24-h ABPM device at one of two visits separated by 1-2 weeks. Study procedures were otherwise identical at both visits.
RESULTS: Mean systolic and diastolic BP for all measured time periods were similar between visits, as was the number of children diagnosed with HTN at each visit.
CONCLUSION: Having confirmed HTN at baseline did not affect the impact of placebo on mean BP. If confirmed, this lack of placebo effect on ABPM measurements may allow for the design of direct comparison pediatric anti-hypertensive trials without a placebo arm.
Authors:
Karen Redwine; Lee Howard; Pippa Simpson; Shun-Hwa Li; Ke Yan; Laura James; Jeffrey Blumer; Janice Sullivan; Robert Ward; Thomas Wells;
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-24
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  27     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-01-24     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1937-42     Citation Subset:  IM    
Affiliation:
Division of Pediatric Nephrology, Department of Pediatrics, University of Arkansas for Medical Sciences & Arkansas Children's Hospital, Little Rock, AR, USA. redwinekarenm@uams.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Blood Pressure*
Blood Pressure Monitoring, Ambulatory*
Child
Child, Preschool
Cross-Over Studies
Female
Humans
Hypertension / diagnosis*,  physiopathology
Male
Office Visits
Placebo Effect
Predictive Value of Tests
Single-Blind Method
United States
Grant Support
ID/Acronym/Agency:
3U10 HD 021324-15S1/HD/NICHD NIH HHS; 5U10 HD 031323-15/HD/NICHD NIH HHS; 5U10HD031324-15/HD/NICHD NIH HHS; KL2 RR029883/RR/NCRR NIH HHS; KL2RR029883/RR/NCRR NIH HHS; U10 HD031323/HD/NICHD NIH HHS; U10 HD031324/HD/NICHD NIH HHS; U10 HD045934/HD/NICHD NIH HHS; U10 HD045934/HD/NICHD NIH HHS; U10 HD045986/HD/NICHD NIH HHS; U10 HD045986/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Insulin resistance in children with primary nephrotic syndrome and normal renal function.
Next Document:  A single bout of exercise increases the expression of glucose but not fatty acid transporters in ske...