Document Detail

Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion.
MedLine Citation:
PMID:  1717954     Owner:  NLM     Status:  MEDLINE    
A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p less than 0.05).
Z Mungan; A Ertan; R A Hammer; A Arimura
Related Documents :
3929374 - Gastric secretion in response to a meal 12-13 h after ranitidine.
8927624 - The effect of pancreatic denervation and atropine on the cholecystokinin-induced pancre...
10218824 - Structure-related inhibitory activity of oleanolic acid glycosides on gastric emptying ...
15143914 - An extensive metabolizer with recurrent ulcer responding to high dose of lansoprazole.
15613924 - Intestinal surgery with activated recombinant factor vii prophylaxis in patients with h...
6623484 - The mouse ciguatoxin bioassay: a dose-response curve and symptomatology analysis.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-62     Citation Subset:  IM    
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenylate Cyclase / metabolism
Amylases / secretion
Neuropeptides / pharmacology*
Pancreas / drug effects*,  enzymology,  secretion
Pituitary Adenylate Cyclase-Activating Polypeptide
Proteins / secretion
Vasoactive Intestinal Peptide / pharmacology
Reg. No./Substance:
0/Adcyap1 protein, rat; 0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Proteins; 37221-79-7/Vasoactive Intestinal Peptide; EC 3.2.1.-/Amylases; EC Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs.
Next Document:  Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase.