Document Detail


Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion.
MedLine Citation:
PMID:  1717954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p less than 0.05).
Authors:
Z Mungan; A Ertan; R A Hammer; A Arimura
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-62     Citation Subset:  IM    
Affiliation:
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / metabolism
Amylases / secretion
Animals
Male
Neuropeptides / pharmacology*
Pancreas / drug effects*,  enzymology,  secretion
Pituitary Adenylate Cyclase-Activating Polypeptide
Proteins / secretion
Rats
Vasoactive Intestinal Peptide / pharmacology
Chemical
Reg. No./Substance:
0/Adcyap1 protein, rat; 0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Proteins; 37221-79-7/Vasoactive Intestinal Peptide; EC 3.2.1.-/Amylases; EC 4.6.1.1/Adenylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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