| Effect of pistachio nuts on serum lipid levels in patients with moderate hypercholesterolemia. | |
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MedLine Citation:
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PMID: 10376778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Elevated serum cholesterol levels play an important role in the development of coronary artery disease. Previous studies have suggested that nut consumption benefits lipid profile. Pistachio nuts are widely available, inexpensive and frequently consumed by the general population. OBJECTIVE: To determine whether substituting 20% of the daily caloric intake in the form of pistachio nuts will improve the lipid profiles of humans with primary, moderate hypercholesterolemia. DESIGN: Controlled, randomized crossover design. SETTING: Outpatient dietary modification, counseling and blood analysis. PATIENTS: Ten patients with moderate hypercholesterolemia. INTERVENTION: Three weeks of dietary modification with 20% caloric intake from pistachio nuts. MEASUREMENTS: Body weight, blood pressure, total cholesterol, LDL, HDL, and triglycerides were monitored. Lipid profiles were analyzed prior to, during and after dietary modification. RESULTS: After three weeks, there was a decrease in total cholesterol (p<0.04), an increase in HDL (p<0.09), a decrease in the total cholesterol/HDL ratio (p<0.01) and a decrease in the LDL/HDL ratio (p<0.02). Triglycerides and LDL levels decreased, but not significantly. Body weight and blood pressure remained constant throughout the study. CONCLUSIONS: Results suggest that eating pistachio nuts instead of other dietary fat calories can improve lipid profiles, thereby decreasing coronary risk. Further studies will be required to confirm these results and to determine the mechanism of this effect. |
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Authors:
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K Edwards; I Kwaw; J Matud; I Kurtz |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 18 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-08-12 Completed Date: 1999-08-12 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 229-32 Citation Subset: IM |
Affiliation:
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Nephrology Division, UCLA School of Medicine, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Weight Cholesterol, HDL / blood* Coronary Disease / etiology Cross-Over Studies Energy Intake Female Humans Hypercholesterolemia / complications, diet therapy* Lipids / blood Male Middle Aged Nuts / therapeutic use* Phytotherapy* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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