Document Detail

Effect of pirozadil on cerebral blood flow in anesthetized dogs.
MedLine Citation:
PMID:  7329165     Owner:  NLM     Status:  MEDLINE    
The effect of pirozadil, a new hypolipidemic agent, on cerebral blood flow was tested in anesthetized dogs and compared to that of two other hypolipidemic/antiatherogenic agents, nicotinic acid and pyridinol carbamate. Nicardipine and papaverine, vasodilator drugs, were used as controls. Measurement of cerebral blood flow was performed by attaching an electromagnetic blood flow transducer to the vertebral artery of the anesthetized dog. Pirozadil's effect on increasing cerebral blood flow was almost equal to that of papaverine, less than that of nicardipine and much greater than that of the other hypolipidemic/antiatherogenic drugs, nicotinic acid and pyridinol carbamate. Pirozadil was also shown to significantly diminish vascular cerebral resistance to a much greater degree than nicotinic acid and pyridinol carbamate.
J Roca; M Grau; J Balasch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  3     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:    1981 Nov-Dec
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cerebrovascular Circulation / drug effects*
Dose-Response Relationship, Drug
Gallic Acid / analogs & derivatives,  pharmacology
Nicotinic Acids / pharmacology
Pyridines / pharmacology*
Time Factors
Reg. No./Substance:
0/Nicotinic Acids; 0/Pyridines; 149-91-7/Gallic Acid; 54110-25-7/pirozadil; 59-67-6/Niacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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