| Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 19787290 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized to add pioglitazone (30 mg) to their therapy or to continue standard therapy. C-reactive protein (CRP) serum levels, metabolic parameters and cardiac autonomic function (assessed by heart rate variability [HRV] on 24-h ECG Holter monitoring) were measured at baseline and after 3 months. Clinical and laboratory variables were similar in the two groups. No significant changes were observed after 3 months for metabolic and anthropometric parameters, except for a mild increase in HDL levels in the pioglitazone group only (P = 0.04 vs. controls). CRP levels decreased significantly at follow-up in the pioglitazone group (3.2 ± 1.97 vs. 2.37 ± 1.56 mg/l) but not in the control group (3.0 ± 1.92 vs. 3.93 ± 2.14 mg/l; P = 0.003). No differences were found in basal and follow-up HRV variables between the two groups. In type 2 diabetic patients pioglitazone exerts favourable effects on inflammation even after short-term therapy. This effect precedes those on metabolic and anthropometric parameters and is not associated with changes in cardiac autonomic function. |
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Authors:
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Roberto Nerla; Dario Pitocco; Francesco Zaccardi; Giancarla Scalone; Ilaria Coviello; Roberto Mollo; Giovanni Ghirlanda; Gaetano A Lanza; Filippo Crea |
Publication Detail:
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Type: Journal Article Date: 2009-09-29 |
Journal Detail:
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Title: Acta diabetologica Volume: 47 ISSN: 1432-5233 ISO Abbreviation: Acta Diabetol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: Germany |
Other Details:
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Languages: eng Pagination: 117-22 Citation Subset: IM |
Affiliation:
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Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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